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ID 16528
Eprint ID
16528
フルテキストURL
Thumnail 93_227.pdf 2.35 MB
タイトル(別表記)
Study of blood coagulation and fibrinolytic activityfollowing Cardiopulmonary bypass
著者
中野 和男 岡山大学医学部第二外科教室
抄録
This study measured blood coagulation parameters (especially antithrombin III(ATIII) and α2 macrogrobulin (α2 MG) in man to clarify the behavior of blood coagulation and activity corresponding to extracoporeal circulation (ECC). Patients who were operated on under ECC were classified into three groups according to the time of ECC as follows, Group I less 60 minutes, Group II 60 to 120 minutes and Group III more than 120 minutes. Results: 1) Blood coagulation activity returned to the preoperative value within 24 hours after operation in each group. Although AT III had recovered within 24 hours, group III remained at lower levels than groups I and II. AT III rose significantly in patients who received warfarin after prosthetic valve replacement and maintained a higher value than those of untreated group. Consumption of AT III was more in mitral valve replacement than in aortic valve. 2) Plasminogen and α2 macroglobulin fell after operation and required one week to return to the preoperative level and group III showed lower values than the other groups. Fibrin and fibrinogen degradation products (FDP) were elevated longer after operation in group III. These results suggest that prolonged ECC tends to consume much AT III and α2 MG and to cause to rise in FDP, which may lead to thrombosis and DIC. It would be beneficial to give an anticoagulant drug (warfarin) to maintain higher AT III during the early postoperative period when blood coagulation activity recovers.
キーワード
体外循環
凝固線溶
Antithrombin III
FDP
発行日
1981-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
93巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
227
終了ページ
247
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/93/3-4/93_3-4_227/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma