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ID 16384
Eprint ID
16384
フルテキストURL
Thumnail 98_1065.pdf 603 KB
タイトル(別表記)
The embryogenic and developmental changes of guanidino compounds in various chick tissues
著者
角谷 隆司 岡山大学医学部脳代謝研究施設機能生化学部門
抄録
Guanidino compounds in various chick tissues were systematically analyzed by high performance liquid chromatography, and the changes in guanidino compound levels were studied during chick embryogenesis and development. In the whole chick embryo, arginine (Arg), creatinine (CRN), guanidinoacetic acid (GAA), β-guanidinopropionic acid (GPA), homoarginine (HArg), guanidine (G) and methylguanidine (MG) were detected. Arg, CRN and GAA appeared after the sixth day of incubation, and the other compounds appeared after the eighth day of incubation. All of the compounds, except for Arg which temporarily decreased on the eighth day of incubation, increased as embryogenesis progressed. In the yolk, Arg, CRN, GAA, GPA, HArg, G and MG were detected. Most of them dramatically increased at the late stage of embryogenesis. A slight increase in Arg, CRN and G in unfertile eggs was also observed after incubation. In the albumen, Arg, CRN, GAA, G and MG were detected. Arg, CRN, GAA, G and MG increased during embryogenesis. A slight increase in Arg, CRN and G in unfertile eggs was also observed after incubation. In the chick brain, liver, kidney and heart, Arg, CRN, GAA, GPA, HArg and MG were detected. Guanidinosuccinic acid and γ-guanidinobutyric acid, which are commonly detectable in the mammalian liver and brain, were not detectable in the chick organs. All guanidino compounds in the chick organs fluctuated greatly during development. GPA decreased as the chicks developed and was not detected in the adult organs. These observations suggest that birds have a different metabolic system of guanidino compounds from that of mammals, and that this system is activated during embryogenesis and affected by various physiological factors after hatching. It was also suggested that guanidino compounds, even at very low levels, might have some important roles in animal tissues during development.
キーワード
グアニジノ化合物
鶏胚
ニワトリ脳
肝臓
腎臓
発行日
1986-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
98巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1065
終了ページ
1077
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/98/11-12/98_11-12_1065/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma