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ID 16176
Eprint ID
16176
フルテキストURL
Thumnail 98_255.pdf 468 KB
タイトル(別表記)
Induction chemotherapy for acute leukemia Part 2. A comparative trial of a combination of daunorubicin and cytosine arabinoside and a combination of aclarubicin and cytosine arabinoside in acute non-lymphocytic leukemia
著者
原 雅道 岡山大学医学部第2内科教室
抄録
A comparative trial of a combination of daunorubicin (DNR) and cytosine arabinoside (ara-C) (Regimen A) and a combination of aclarubicin (ACR) and ara-C (Regimen B) was performed. Sixteen patients with acute non-lymphocytic leukemia, previously untreated, included in this study. Five of 8 patients, 62.5%, obtained a complete remission (CR) with both Regimen A and B. The days until CR varied from 37 to 46 in Regimen A and from 22 to 56 in Regimen B. The total doses of DNR and ara-C in Regimen A were from 100 to 240mg and from 640 to 1,120mg, respectively. Those of ACR and ara-C in Regimen B were from 180 to 300mg and from 660 to 1,000mg, respectively. In a comparative study of hematological changes, toxic effects on peripheral white blood cells, platelets and nucleated cells in bone marrow tended to appear later in Regimen B than in Regimen A. Side effects on the digestive system such as nausea and vomiting and vascular pain were more frequently recognized in patients treated with Regimen B, although they were managed by symptomatic treatment. The present comparative study indicated that a new antileukemic anthracycline, ACR, has the same therapeutic activity against ANLL as DNR in combination with ara-C.
キーワード
急性白血病寛解導入療法
aclarubicin
daunorubicin
cytosine arabinoside
発行日
1986-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
98巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
255
終了ページ
264
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.journalarchive.https://www.jstage.jst.go.jp/article/joma1947/98/3-4/98_3-4_255/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma