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ID 14170
Eprint ID
14170
フルテキストURL
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タイトル(別表記)
Studies on the mechanism and treatment of intractable asthma Part 2. The mechanism of specific thromboxane A(2) synthetase inhibitor in cell-mediated allergy in intractable asthmatics
著者
金廣 有彦 岡山大学医学部第二内科学教室
抄録
The specific thromboxane A(2) (TXA(2)) synthetase inhibitor (OKY-046) seems to be a useful drug in the treatment of intractable asthmatics. In this study, to clarify the action mechanism of OKY-046 and the relationship between TXA(2) and prostaglandin E(2) (PGE(2)) in cell-mediated allergy, the effect of the TXA(2) receptor antagonist (AA-2414), TXA2 analogue (STA(2)) and PGE(2) for peripheral blood mononuclear cells in adult intractable asthmatics was studied. OKY-046 significantly suppressed TXB(2) production and increased PGE(2) production from the peripheral blood mononuclear cells stimulated by PHA and Candida antigen, but AA-2414 had no effect. AA-2414 suppressed lymphocyte blastgenesis, but did not suppress significantly interleukin-2 (IL-2) or neutrophil chemotactic factor (NCF) production. Furthermore, STA(2) increased lymphocyte blastgenesis stimulated by Candida antigen partially, but not dose-dependently. On the other hand, PGE(2) suppressed significantly lymphocyte blastgenesis and IL-2 and NCF production in a dose-dependent manner. These findings suggest that the action mechanism of OKY-046 is a suppressive effect of cell-mediated allergy, and that TXA(2) and PGE(2) play an important role in the mechanism of intractable asthma.
キーワード
Intractable asthma
thromboxane A(2)
prostaglandin E(2)
thromboxane A(2) synthetase inhibitor (OKY-046)
thromboxane A(2) receptor antagonist (AA-2414)
備考
原著
発行日
1992-08
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
735
終了ページ
746
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_735/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma