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ID 14045
Eprint ID
14045
フルテキストURL
Thumnail 106_451.pdf 549 KB
タイトル(別表記)
The role of the KATP channel in functional and reactive myocardial hyperemia
著者
小林 博夫 岡山大学医学部循環器内科学教室
抄録
To evaluate the role of the KATP channel in regulating coronary tonus in response to increases in myocardial oxygen conaumption, and reactive hypermia following ischemia, coronary blood flow was measured with glibenclamide, a KATP channel blocker (50μmol/l ic.) and pinacidil, a KATP channel opener, (10μmol/l ic.) The following interventions were applied in the control and during intracoronary infusions of glibenclamide alone or glibenclamide plus pinacidil : 1) intravenous infusion of isoproternol (0.125μg/kg/min), 2) aortic constriction to raise the mean aortic pressure by 30%. The slope of the regression line of coronary conductance of mycardial oxygen consumption was significantly decreased with glibenclamide (p<0.05), but returned to the baseline with pinacidil, both during isoproterenol infunsion and aortic constriction. Reactive hyperemia following a 20-sec coronary occlusion was also attennuated with glibenclamide and recovered with pinacidil. These findings suggest that the KATP channel regulates coronary artery tonus during the increase in myocardial oxygen consumption and transient myocardial ischemia.
キーワード
KATP channel
glibenclamide
myocardial oxygen consumption
coronary conductance
備考
原著
発行日
1994
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
451
終了ページ
460
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_451/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
参考文献
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言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
2
Eprints Journal Name
joma