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ID 50687
FullText URL
Author
Asagi, Akinori
Ohta, Koji
Nasu, Junichirou
Tanada, Minoru
Nadano, Seijin
Nishimura, Rieko
Teramoto, Norihiro
Inoue, Takeshi
Iguchi, Haruo
Abstract
Objectives: Fluorodeoxyglucose (FDG)-positron emission tomography/contrast-enhanced computed tomography (PET/CE-CT) involving whole-body scanning first by non-CE-CT and FDG-PET followed by CE-CT has been used for detailed examination of pancreatic lesions. We evaluated PET/CE-CT images with regard to differential diagnosis, staging, treatment response, and postoperative recurrence in pancreatic cancer. Methods: Positron emission tomography/CE-CT was conducted in 108 patients with pancreatic cancer and in 41 patients with other pancreatic tumor diseases. Results: The maximum standardized uptake value (SUVmax) overlapped in benign and malignant cases, suggesting that differential diagnosis of pancreatic tumors based on the SUVmax is difficult. In the evaluation of staging in 31 resectable pancreatic cancer by PET/CE-CT, the diagnostic accuracy rate was more than 80% for most factors concerning local invasion and 94% for distant metastasis but only 42% for lymph node metastasis. Significant positive correlations were found between the SUVmax and tumor size/markers, suggesting that SUVmax may be a useful indicator for the treatment response. Regarding the diagnosis of the postoperative recurrence, PET/CE-CT correctly detected local recurrence in all the 11 cases of recurrence, whereas abdominal CE-CT detected only 7 of 11 cases, suggesting that PET/CE-CT is superior in this context. Conclusions: Positron emission tomography/CE-CT is useful for the clinical management of pancreatic cancer.
Keywords
contrast-enhanced PET/CT
differential diagnosis
clinical management
pancreatic cancer
Published Date
2013-01
Publication Title
Pancreas
Volume
volume42
Issue
issue1
Publisher
Lippincott Williams & Wilkins
Start Page
11
End Page
19
ISSN
0885-3177
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1097/MPA.0b013e3182550d77
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50660
language
英語
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author
Refereed
True
DOI
Web of Sience KeyUT