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ID 50694
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Author
Kawamoto, Hirofumi
Hirao, Ken
Sakakihara, Ichiro
Yamamoto, Naoki
Noma, Yasuhiro
Fujii, Masakuni
Ogawa, Tsuneyoshi
Ishida, Etsuji
Okada, Hiroyuki
Abstract
Background: Measurement of objective response to chemotherapy using imaging modalities is sometimes difficult in pancreatic cancer (PC). We aimed to verify whether monitoring of serum tumor markers (TMs), namely carcinoembryonic antigen, CA19-9, DUPAN-2, SPan-1, can facilitate earlier confirmation of treatment failure. Methods: Monitoring of serum TMs and computed tomography were performed every 4 weeks until progression of disease in 90 patients with PC undergoing gemcitabine therapy. In Group A (January 2006 October 2007), we analyzed the fluctuation rates of TMs with high pretreatment positive rates, and defined the criteria of progressive disease under TM monitoring (TM-PD). In Group B (November 2007 October 2008), we calculated the time to progression (TTP) under this TM-PD criteria, which was compared with the UP under the RECIST criteria. Results: CA19-9 and SPan-1 had the highest pretreatment positive rates: 83% and 90%, respectively. In Group A (CA19-9, n = 38; SPan-1, n = 36), TM-PD criteria were defined as follows: fluctuation rates were >25% for a month or >= 10% for 2 consecutive months in CA19-9, and >= 10% for a month in SPan-1. In Group B (CA19-9, n = 18; SPan-1, n = 17), under these criteria, one-month earlier confirmation of treatment failure was feasible in 61% by CA19-9 and 59% by SPan-1. Furthermore, the combination could facilitate this determination in 72% (35/49), significantly better than CA19-9 alone (P = 0.004). Conclusion: Monitoring of serum CA19-9 and Span-1 is helpful for earlier confirmation of treatment failure during gemcitabine therapy in PC.
Keywords
Pancreas
Pancreatic cancer
Tumor marker
Gemcitabine
Diagnosis
Published Date
2012-09
Publication Title
Pancreatology
Volume
volume12
Issue
issue5
Publisher
Karger
Start Page
409
End Page
416
ISSN
1424-3903
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1016/j.pan.2012.07.009
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50663
language
英語
Copyright Holders
Copyright (C) 2012, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
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Refereed
True
DOI
Web of Sience KeyUT