FullText URL Int_J_Hematol_105_6_812.pdf
Author Nishimori, Hisakazu| Fujii, Nobuharu| Fujii, Keiko| Ikeda, Tohru| Asano, Naomi| Ogo, Hiroaki| Yamakawa, Miwa| Takagi, Naoe| Otsuka, Fumio| Ikeda, Kazuma|
Abstract Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0-17 years old (16/320, 5.0%) than in patients 18 years and older (71/3872, 1.8%). In particular, VVRs occurred more frequently in those 10-13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection.
Keywords Autologous blood donation Vasovagal reactions
Note This is an Accepted Manuscript of an article published by Springer
Published Date 2017-06
Publication Title International Journal of Hematology
Volume volume105
Issue issue6
Publisher Elsevier Science
Start Page 812
End Page 818
ISSN 0925-5710
NCID AA10797094
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28271415
DOI 10.1007/s12185-017-2204-6
Web of Sience KeyUT 000401324100014
Related Url isVersionOf https://doi.org/10.1007/s12185-017-2204-6
FullText URL Dent_Material_33_3_e124.pdf
Author Yoshihara, Kumiko| Nagaoka, Noriyuki| Maruo, Yukinori| Nishigawa, Goro| Irie, Masao| Yoshida, Yasuhiro| Meerbeekf, Bart Van|
Abstract  OBJECTIVE:  CAD-CAM blocks to fabricate semi-direct and indirect restorations are available in different sorts of ceramics as well as composite. In order to bond restorations prepared out of composite blocks into tooth cavities, it is recommended to gently sandblast the surface prior to the application of a primer/adhesive. Today, the effect of sandblasting composite block surfaces has not thoroughly been investigated. In this study, the ultra-structure of composite CAD-CAM blocks was investigated with special attention to the effect of sandblasting on the surface topography and of silanization on the bonding performance.  METHODS:  Five different composite CAD-CAM blocks were involved. We correlatively investigated their structural and chemical composition using X-ray diffraction (XRD), energy dispersion spectroscopy (EDS), scanning electron microscopy (SEM) and (scanning) transmission electron microscopy ((S)TEM). The effect of sandblasting was also imaged in cross-section and at the interface with composite cement. Finally, we measured the shear bond strength to the sandblasted block surface with and without silanization.  RESULTS:  All composite blocks revealed a different ultra-structure. Sandblasting increased surface roughness and resulted in an irregular surface with some filler exposure. Sandblasting also damaged the surface. When the sandblasted composite blocks were silanized, superior bonding receptiveness in terms of higher bond strength was achieved except for Shofu Block HC.  SIGNIFICANCE:  Sandblasting followed by silanization improved the bond strength to composite CAD-CAM blocks. However, sandblasting may also damage the composite CAD-CAM block surface. For the composite CAD-CAM block Shofu Block HC, the damage was so severe that silanization did not improve bond strength.
Keywords CAD–CAM bond strength composite sandblast silane coupling agent
Published Date 2017-03
Publication Title Dental Materials
Volume volume33
Issue issue3
Publisher Elsevier Science
Start Page e124
End Page e135
ISSN 0109-5641
NCID AA10443138
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28057347
DOI 10.1016/j.dental.2016.12.003
Web of Sience KeyUT 000396409900004
Related Url isVerionOf https://doi.org/10.1016/j.dental.2016.12.003
FullText URL K0005288_other.pdf
Author Sejima, Hiroe| Mori, Kyoko| Ariumi, Yasuo| Ikeda, Masanori| Kato, Nobuyuki|
Abstract  Persistent hepatitis C virus (HCV) infection frequently causes hepatocellular carcinoma. However, the mechanisms of HCV-associated hepatocarcinogenesis and disease progression are unclear. Although the human hepatoma cell line, HuH-7, has been widely used as the only cell culture system for robust HCV replication, we recently developed new human hepatoma Li23 cell line-derived OL, OL8, OL11, and OL14 cells, in which genome-length HCV RNA (O strain of genotype 1b) efficiently replicates. OL, OL8, OL11, and OL14 cells were cultured for more than 2 years. We prepared cured cells from OL8 and OL11 cells by interferon-γ treatment. The cured cells were also cultured for more than 2 years. cDNA microarray and RT-PCR analyses were performed using total RNAs prepared from these cells. We first selected several hundred highly or moderately expressed probes, the expression levels of which were upregulated or downregulated at ratios of more than 2 or less than 0.5 in each set of compared cells (e.g., parent OL8 cells versus OL8 cells cultured for 2 years). From among these probes, we next selected those whose expression levels commonly changed during a 2-year culture of genome-length HCV RNA-replicating cells, but which did not change during a 2-year culture period in cured cells. We further examined the expression levels of the selected candidate genes by RT-PCR analysis using additional specimens from the cells cultured for 3.5 years. Reproducibility of the RT-PCR analysis using specimens from recultured cells was also confirmed. Finally, we identified 5 upregulated genes and 4 downregulated genes, the expression levels of which were irreversibly altered during 3.5-year replication of HCV RNA. These genes may play roles in the optimization of the environment in HCV RNA replication, or may play key roles in the progression of HCV-associated hepatic diseases.
Keywords HCV HCV RNA replication system Li23 cells Long-term RNA replication Upregulated host genes Downregulated host genes
Note 学位審査副論文
Published Date 2012-07
Publication Title Virus Research
Volume volume167
Issue issue1
Publisher Elsevier Science
Start Page 74
End Page 85
ISSN 0168-1702
NCID AA10642076
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 22579597
DOI 10.1016/j.virusres.2012.04.008
Web of Sience KeyUT 000305496700010
Related Url https://doi.org/10.1016/j.virusres.2012.04.008 http://ousar.lib.okayama-u.ac.jp/54271