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Author
Adachi, R.
Takaya, T.
Kuriyama, K.
Higashibata, A.
Ishioka, N.
Kagawa, H.
Abstract
We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
Keywords
Spaceflight
Microgravity
Myosin heavy chain
Paramyosin
C. elegans
Mutation
Note
Published with permission from the copyright holder.
This is a author's copy,as published in Advances in Space Research , 2008, volume 41, issue 5, pp816-823.
Publisher URL: http://dx.doi.org/10.1016/j.asr.2007.10.016
Copyright © 2007 COSPAR. Published by Elsevier Ltd. All rights reserved.
Published Date
2008
Publication Title
Advances in Space Research
Volume
volume41
Issue
issue5
Publisher
Elsevier Ltd.
Start Page
816
End Page
823
ISSN
0273-1177
NCID
AA10636539
Content Type
Journal Article
language
英語
Copyright Holders
© 2007 COSPAR Published by Elsevier Ltd.
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author
Refereed
True
DOI
Web of Sience KeyUT
Submission Path
biology_general/38