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ID 55197
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Okada, Masahiro Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Nakai, Akira Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hara Emilio, Satoshi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Taguchi, Tetsushi Polymeric Biomaterials Group, RCFM, National Institute for Materials Science
Nakano, Takayoshi Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
Matsumoto, Takuya Department of Biomaterials, Okayama University
Abstract
Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues.
Keywords
Hydroxyapatite
Nanoparticle
Solid adhesive
Wet adhesion
Published Date
2017-05
Publication Title
Acta Biomaterialia
Volume
volume57
Publisher
Elsevier B.V.
Start Page
404
End Page
413
ISSN
1742-7061
NCID
AA12033647
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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Related Url
https://doi.org/10.1016/j.actbio.2017.05.014