このエントリーをはてなブックマークに追加
ID 34122
FullText URL
Author
Kurauchi, Tomomi
Fujinami, Yoshihito
Isogai, Emiko
Isogai, Hiroshi
Abstract
Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet’s disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD. To investigate the pathogenesis of this isolate, we examined neutrophil 5 reactions and level of cytokine production by lymphocytes after stimulation with the strain. The reactions of neutrophils were examined by chemiluminescence assay using whole blood. The amounts of interferon gamma (IFN-g) and interleukin (IL)-4, IL-8, IL-10, and IL-12 produced by peripheral blood mononuclear cells (PBMCs) were measured by ELISA. 10 Strain BD113-20 activated neutrophils from patients with ABD and healthy volunteers, and, in addition it increased IFN-g production by lymphocytes. Lymphocyte from the patients with ABD showed a dominant T helper 1 (Th-1) immune response. Results indicated that both bacterial stimulation and host hypersensitivity might be involved in the symptoms and pathogenesis of ABD.
Keywords
Adamantiades-Behcet's disease
Streptococcus sanguinis
neutrophil
chemiluminescence
IL-8
T helper-1
IFN-gamma
IL-12
Note
Digital Object Identifer:10.1016/j.femsim.2004.07.007
The Published with permission from the copyright holder. This is the author's copy, as published in FEMS Immunology and Medical Microbiology, February 2005, Volume 43, Issue 2, Pages 125-131.
Publisher URL:http://dx.doi.org/10.1016/j.femsim.2004.07.007
Direct access to Thomson Web of Science record
Copyright © 2004 Federation of European Microbiological Societies Published by Elsevier B.V. All rights reserved.
Published Date
2005-02-01
Publication Title
FEMS Immunology and Medical Microbiology
Volume
volume43
Issue
issue2
Publisher
Elsevier B.V.
Start Page
125
End Page
131
Content Type
Journal Article
language
英語
Copyright Holders
Federation of European Microbiological Societies. Published by Elsevier B.V.
Refereed
True
DOI
Web of Sience KeyUT
Submission Path
microbiology_and_immunology/5