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ID 55411
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Nishimura, Ryo Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University
Okuda, Kiyoshi Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University
Abstract
There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1. Ovarian function has several phases that change day by day, including ovulation, follicular growth and corpus luteum formation and regression. These phases are regulated by many factors, including pituitary hormones and local hormones, such as steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis because transcription of the potent angiogenic factor vascular endothelial growth factor (VEGF) is regulated by HIF1. Follicular development and luteal formation are accompanied by a marked increase in angiogenesis assisted by HIF1-VEGF signalling. Hypoxia is also one of the factors that induces luteolysis by suppressing progesterone synthesis and by promoting apoptosis of luteal cells. The present review focuses on recent studies of hypoxic conditions, as well as HIF1-regulated genes and proteins, in the regulation of ovarian function.
Keywords
angiogenesis
apoptosis
corpus luteum
follicular development
luteal formation
luteal regression
steroidogenesis
Note
This is an Accepted Manuscript of an article published by CSIRO Publishing
Published Date
2015-05
Publication Title
Reproduction, Fertility and Development
Volume
volume28
Issue
issue10
Publisher
CSIRO Publishing
Start Page
1479
End Page
1486
ISSN
1031-3613
NCID
AA10718189
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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isVersionOf https://doi.org/10.1071/RD15010