このエントリーをはてなブックマークに追加
ID 50624
FullText URL
Author
Inoue, Junko
Hida, Kazuyuki
Takatori, Yuji
Kojo, Shoichirou
Akagi, Shigeru
Nakao, Kazushi
Miyatake, Nobuyuki
McDonald, John F.
Abstract
Background: Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients. Methods: Healthy Japanese control volunteers (control; n = 95, 49.9 +/- 6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4 +/- 10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system. Results: The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; Vaspin(High) group), while the rest of the population exhibited lower levels (< 3 ng/ml; Vaspin(Low) group). By comparing the patients in the Vaspin(Low) group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87 +/- 0.24 ng/ml) than in the HD patients (0.32 +/- 0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects. Conclusions: The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin(Low) group.
Keywords
Adipokine
End-stage renal disease
Hemodialysis
Published Date
2012-12-03
Publication Title
BMC Nephrology
Volume
volume13
Publisher
Biomed Central Ltd
ISSN
1471-2369
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1186/1471-2369-13-163
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50624
language
英語
File Version
publisher
Refereed
True
DOI
Web of Sience KeyUT