FullText URL K0005596_other1.pdf
Author Thar Htet San| Fujisawa, Masayoshi| Fushimi, Soichiro| Soe, Lamin| Ngu Wah Min| Yoshimura, Teizo| Ohara, Toshiaki| Myint Myint Yee| Oda, Shinsuke| Matsukawa , Akihiro|
Abstract BACKGROUND: Breast cancer is the most common cancer in Myanmar women. Revealing the hormonal receptor status, human epidermal growth factor receptor 2 (HER2) and Ki-67 expression is useful for estimating patient prognosis as well as determination of treatment strategy. However, immunohistochemical features and classification of molecular subtypes in breast cancers from Myanmar remain unknown. METHODS: The clinicopathological features of 91 breast cancers from Myanmar women were examined. Immunohistochemistry was performed on tissue specimens with antibodies to estrogen receptor (ER), progesterone receptor (PgR), HER2, Ki-67, cytokeratin (CK)5/6 and CK14. Immunohistochemistry-based molecular subtyping was conducted. RESULTS: Breast cancers in Myanmar women were relatively large, high grade with frequent metastatic lymph nodes. Of the 91 patients, tumors with ER positive, PgR positive, and HER2 positive were 57.1%, 37.4%, and 28.6%, respectively. The most prevalent subtype was luminal B (HER2-) (39.6%), followed by HER2 (22.0%), triple negative (TN)-basal-like (12.1%), luminal A (11.0%), TN-null (8.8%) and luminal B (HER2+) (6.6%). The mean Ki-67 expression of 91 cases was 33.9% (33.9% ± 19.2%) and the median was 28% (range; 4%-90%). The mean Ki-67 expression of luminal A, luminal B, HER2 and TN-basal-like/ null was 7%, 30%, 40%, and 57%/43%, respectively. A higher Ki-67 expression significantly correlated with a higher grade, larger size and higher stage of malignancy. CONCLUSIONS: We, for the first time, investigated the histopathological features of breast cancers from Myanmar women. Myanmar breast cancers appeared to be aggressive in nature, as evidenced by high frequency of poor-prognosis subtypes with high level of Ki-67 expression.
Keywords Breast cancer molecular subtypes Ki-67 expression Myanmar
Note 学位審査副論文
Published Date 2017-06-25
Publication Title Asian Pacific journal of cancer prevention
Volume volume18
Issue issue6
Publisher Asian Pacific Organization for Cancer Prevention
Start Page 1617
End Page 1621
ISSN 1513-7368
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 28670879
DOI 10.22034/APJCP.2017.18.6.1617
Related Url isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521