Title Alternative Parkinson's disease from a viewpoint of regenerative medicine
FullText URL 116_17.pdf
Author Date, Isao|
Abstract It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.
Keywords Parkinson's disease neural transplantation regeneration
Publication Title 岡山医学会雑誌
Published Date 2004-05-31
Volume volume116
Issue issue1
Start Page 17
End Page 27
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.116.1_17
NAID 10013089196
FullText URL 115_145.pdf
Author 松井 利浩| 伊達 勲|
Keywords neuroendoscope neurosurgery hydrocephalus third ventriculostomy biopsy
Publication Title 岡山医学会雑誌
Published Date 2005-09-30
Volume volume115
Issue issue2
Start Page 145
End Page 150
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.115.2_145
NAID 10011896852
Title Alternative Two cases of acute pulmonary embolism after esophageal cancer operation
FullText URL 118_41.pdf
Author Kanazawa, Takashi| Watababe, Nobuyuki| Naomoto, Yoshio| Kobayashi, Masahiko| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Kobayashi, Naoya| Fujiwara, Tohsiyoshi| Matsubara, Nagahide| Iwagaki, Hiromi| Matsuoka, Junji| Tanaka, Noriaki|
Abstract We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation、 he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy.
Keywords 食道癌 (esophageal cancer) 肺塞栓症 (pulmonary embolism) 深部静脈血栓症 (deep venous thrombs)
Publication Title 岡山医学会雑誌
Published Date 2006-05-01
Volume volume118
Issue issue1
Start Page 41
End Page 45
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.1_41
NAID 10017417131
FullText URL 118_205.pdf
Author 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲|
Keywords プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン
Publication Title 岡山医学会雑誌
Published Date 2007-01-04
Volume volume118
Issue issue3
Start Page 205
End Page 208
ISSN 00301558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.3_205
NAID 10018454083
FullText URL 118_9.pdf
Author 梅岡 達生| 川嶋 健| 香川 俊輔| 寺石 文則| 滝 正樹| 京 哲| 永井 勝幸| 浦田 泰生| 田中 紀章| 藤原 俊義|
Keywords GFP アデノウイルス テロメラーゼ 増幅 遺伝子治療
Publication Title 岡山医学会雑誌
Published Date 2006-05-01
Volume volume118
Issue issue1
Start Page 9
End Page 15
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.1_9
NAID 10017417061
FullText URL 118_99.pdf
Author 安原 隆雄| 新郷 哲郎| 小林 和樹| 竹内 亮| 矢野 昭正| 村岡 賢一郎| 亀田 雅博| 元 文姫| 早瀬 仁志| 上利 崇| 松井 利浩| 三好 康之| 伊達 勲|
Keywords カプセル化細胞移植 グリア細胞株由来神経栄養因子 (GDNF) 血管内皮成長因子 (VEGF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2006-09-01
Volume volume118
Issue issue2
Start Page 99
End Page 103
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.2_99
NAID 10018059355
Title Alternative Adult neural stem and progenitor cell transplantation in CNS diseases
FullText URL 120_153.pdf
Author Kameda, Masahiro| Shingo, Tetsuro| Muraoka, Kenichiro| Takahashi, Kazuya| Yasuhara, Takao| Date, Isao|
Keywords 成体由来神経幹細胞 脳内移植 グリア細胞株由来神経栄養因子(GDNF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 153
End Page 157
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.153
NAID 120002310550
Title Alternative Novel protein transduction method for cerebral arteries using 11R
FullText URL 120_129.pdf
Author Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
Keywords cerebral vasospasm 11R protein transduction method
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 129
End Page 133
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.129
NAID 120002310545
Title Alternative Adenoviral p53 gene therapy for lung cancer
FullText URL 119_229.pdf
Author Fujiwara, Toshiyoshi| Tanaka, Noriaki|
Abstract To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit.
Keywords p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial)
Publication Title 岡山医学会雑誌
Published Date 2008-01-04
Volume volume119
Issue issue3
Start Page 229
End Page 234
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.119.229
NAID 10020282723
Title Alternative In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
FullText URL 120_01_013_021.pdf
Author Kishimoto, Hiroyuki| Kojima, Toru| Watanabe, Yuichi| Kagawa, Shunsuke| Fujiwara, Toshiya| Uno, Futoshi| Teraishi, Fuminori| Kyo, Satoru| Mizuguchi, Hiroyuki| Hashimoto, Yuuri| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Keywords GFP アデノウイルス ヒトテロメラーゼ逆転写酵素
Publication Title 岡山医学会雑誌
Published Date 2008-05-01
Volume volume120
Issue issue1
Start Page 13
End Page 21
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.13
NAID 10024170197
Title Alternative Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously
Author Katsura, Yuki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Maeda, Naomi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Abstract When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery.
Keywords 食道アカラシア (achalasia) 再手術 (reoperation) 食道亜全摘 (esophagectomy)
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 41
End Page 44
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.41
Title Alternative Review of the 31st Annual Meeting of the Japanese Society for NeuroEndovascular Therapy (JSNET 2015 Okayama)
FullText URL 128_151.pdf
Author Sugiu, Kenji|
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 151
End Page 153
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.151
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.151
NAID 130005262641
Title Alternative Incisional hernia repair after wide excision of the iliac bone
FullText URL 128_117.pdf
Author Tsukuda, Kazunori| Asano, Hiroaki| Mandai, Yasuhiro| Fujiwara, Toshiyoshi|
Abstract  The patient was a 46-year old Japanese female who had undergone wide excision of the iliac bone and hip transposition at our institute's orthopedics department 2 years earlier. She presented with a growing incisional hernia and was transferred to our gastroenterological surgery department for surgical treatment. We planned a mesh repair for the incisional hernia, which protruded over the right iliac bone. The dimensions of the abdominal defect were 15×9 cm, and we used prolene mesh to repair the defect. The mesh was fixed at the inner part of the iliac bone, folded back at the iliac horn and fixed to the abdominal oblique muscles. The postoperative course was smooth, and recurrence was not seen at 3.5 years after the operation. An incisional hernia as seen in this patient's case is very rare, but we found that the underlay technique and prolene mesh were very useful for the three-dimensional hernia repair.
Keywords 腹壁瘢痕ヘルニア(incisional hernia) 腸骨軟骨肉腫(chondrosarcoma of the iliac bone) 腸骨広範囲切除術(wide excision of the iliac bone) プロリーンメッシュ(prolene mesh)
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 117
End Page 120
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.117
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.117
NAID 130005262528
Title Alternative Hosting the 18th JASMEE Academic Meeting in Okayama
FullText URL 128_69.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 69
End Page 70
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.69
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.69
NAID 120005752921
Title Alternative The 2014 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2014 Sunada Prize)
FullText URL 128_5.pdf
Author Hishikawa, Tomohito|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 5
End Page 7
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.5
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.5
NAID 130005149612
Title Alternative Hosting the 16th Annual Meeting of the Japanese Society for Normal Pressure Hydrocephalus
FullText URL 127_259.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 259
End Page 260
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.259
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.259
NAID 130005116806
Title Alternative Successful laparoscopic resection of a cecal tumor in a 95-year-old man
FullText URL 127_117.pdf
Author Watanabe, Ayako| Inada, Ryo| Nagasaka, Takeshi| Yagi, Tomohiko| Matsumoto, Hijiri| Toshima, Toshiaki| Kikuchi, Satoru| Kuroda, Shinshi| Kondo, Yoshitaka| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi|
Abstract We report a successful laparoscopic resection of a cecal tumor in a 95-year-old Japanese man. The patient visited an initial hospital with a complaint of constipation in March 2014. Computed tomography scan and colonoscopy showed a stenotic ileocecal cancer with pericolic lymph node metastases, and he was referred to our department for management. Since his general condition was maintained, we performed a laparoscopic ileocecal resection with regional lymph node dissection for the patient. The operation achieved curative resection, and the tumor was diagnosed as a moderately differentiated adenocarcinoma and graded as pStage IIIa (pT3, pN0, pM0) according to the Japanese Classification of Colorectal Carcinoma, eighth edition. He was discharged on the 11th postoperative day without perioperative complications. Several large-scale randomized controlled trials (RCTs) revealed that laparoscopic surgeries for colorectal cancers have some advantages compared to open surgeries, including superior short-term outcomes and comparable long-term outcomes. Unfortunately, since these RCTs did not include enough elderly patients, the safety and feasibility of laparoscopic surgery for extremely elderly patients are still unknown. With respect to less-invasive procedures, these advantages of laparoscopic surgery are also thought to be the advantages for elderly colorectal cancer patients.
Keywords 超高齢者(extremely elderly patient) 大腸癌(colorectal cancer) 腹腔鏡手術(laparoscopic surgery)
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 117
End Page 121
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.117
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.117
NAID 130005096253
Title Alternative A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
FullText URL 126_45.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Koujima, Takeshi| Ohara, Toshiaki| Tanabe, Shunsuke| Noma, Kazuhiro| Sakurama, Kazuhumi| Fujiwara, Toshiyosi|
Abstract  We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
Keywords 食道(esophagus) 悪性黒色腫(malignant melanoma)
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 45
End Page 48
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.45
NAID 130004505808
Title Alternative Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
FullText URL 126_39.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Koujima, Takeshi| Ohara, Toshiaki| Tanabe, Shunsuke| Noma, Kazuhiro| Sakurama, Kazuhumi| Fujiwara, Toshiyosi|
Abstract  Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
Keywords 食道癌(esophageal cancer) 内分泌細胞癌(endocrine cell carcinoma) DCF療法(DCF treatment)
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 39
End Page 43
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.39
NAID 130004505807
Author 橘 史朗|
Publication Title Journal of Okayama Medical Association
Published Date 2019-08-01
Volume volume131
Issue issue2
Start Page 107
End Page 108
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher