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ID 60711
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Shear, Alex Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani
Nishihiro, Shingo Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
Hishikawa, Tomohito Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID publons researchmap
Hiramatsu, Masafumi Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
Sugiu, Kenji Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Yasuhara, Takao Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Date, Isao Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Abstract
Angiogenesis involves new blood vessels sprouting from preexisting blood vessels. This process may serve to improve brain circulation. Moyamoya disease (MMD) is a cerebrovascular disorder causing intracranial stenosis which significantly reduces the blood supply to the brain. Mainly stroke is the first symptom of the disorder, so treatments that reduce the risk of stroke are used for patients with MMD. To prevent stroke for those with chronic cerebral hypoperfusion, more blood needs to flow to the brain, which was thought to be achieved by enhancing angiogenesis. Indirect bypass surgery, such as encephalo-myo-synangiosis (EMS), is used for revascularization. However, EMS alone sometimes cannot provide enough circulation to avoid ischemic strokes. The current study examined if EMS combined with high-mobility group box-1 (HMGB1) and vascular endothelial growth factor (VEGF) enhanced angiogenesis and increased cerebral circulation. The results indicated that HMGB1 administered with EMS increased angiogenesis through a VEGF-dependent mechanism. In addition, exercising and stem cell transplantation possess possible means to increase angiogenesis. Overall, EMS with gene therapy, maintaining fitness, and stem cell utilization may prevent or help one recover from stroke by enhancing brain angiogenesis. Thus, these treatments may be applicable for patients with MMD. This paper is a review article. Referred literature in this paper has been listed in the references section. The datasets supporting the conclusions of this article are available online by searching various databases, including PubMed.
Keywords
Angiogenesis
cerebral hypoperfusion
encephalo-myo-synangiosis
endothelial progenitor cells
high-mobility group box-1
revascularization
vascular endothelial growth factor
Published Date
2019-09-30
Publication Title
Brain Circulation
Volume
volume5
Issue
issue3
Publisher
Wolters Kluwer
Start Page
119
End Page
123
ISSN
2394-8108
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 Brain Circulation
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PubMed ID
DOI
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Related Url
isVersionOf https://doi.org/10.4103/bc.bc_33_19
License
https://creativecommons.org/licenses/by-nc-sa/4.0/