Front_Microbiol_4_144.pdf 269 KB
Chowdhury, Goutam Department of Bacteriology, National Institute of Cholera and Enteric Diseases
Joshi, Sangeeta Manipal Hospital
Bhattacharya, Sanjay Tata Medical Center
Sekar, Uma Sri Ramachandra Medical Centre
Birajdar, Balaji Metropolis Healthcare Ltd-Global Hospital
Bhattacharyya, Arpita Metropolis Healthcare Ltd-Global Hospital
Shinoda, Sumio Collaborative Research Centre of Okayama University for Infectious Diseases in India, National Institute of Cholera and Enteric Diseases
Ramamurthy, Thandavarayan Translational Health Science and Technology Institute, NCR Biotech Science Cluster
Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.
This work was supported by the Japan Initiative for Global Research Network for Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology, Japan.
frontiers in Microbiology
Frontiers Research Foundation
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Collaborative Research of Okayama University for Infectious Diseases in India