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Title Alternative
Effect of postprandial hyperglycemia and hyperinsulinemia on vascular responsiveness
Author
Takatori, Shingo
Iwatani, Yukiko
Yamawaki, Kosuke
Miyashita, Satoko
Yabumae, Nana
Takayama, Fusako
Mio, Mitsunobu
Kawasaki, Hiromu Kaken ID publons
Abstract
Recent clinical studies demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension. Therefore, we investigated influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. Changes in vascular responses to spinal cord stimulation (SCS) and intravenous bolus injections of noradrenaline, angiotensin II, calcitonin generelated peptide (CGRP), acetylcholine and sodium nitroprusside (SNP) were studied by infusing various concentration of glucose or insulin. Continuous glucose infusion, which increased both blood glucose and serum insulin levels, significantly augmented adrenergic nerve-mediated pressor responses to SCS without affecting injection of pressor responses to noradrenaline or angiotensin II. In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP. In pithed rats treated with octreotide, which increased blood glucose without increasing serum insulin levels, glucose infusion caused only significant augmentation of adrenergic nervemediated pressor responses. Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemic, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses. The present results suggest that acute hyperglycemia and hyperinsulinemia increases adrenergic nerve-mediated vasoconstriction, which is partly associated with the blunted CGRPergic nerve function, and that plasma insulin concentration associated with hyperglycemia may be responsible for alteration of neuronal vascular regulation.
Keywords
hyperglycemia
hyperinsulinemia
Calcitonin gene-related peptide nerve
Note
コンテンツの著作権は日本薬学会が有します。
Published Date
2008-03-01
Publication Title
藥學雜誌
Publication Title Alternative
Yakugaku zasshi
Volume
volume128
Issue
issue3
Publisher
日本薬学会
Publisher Alternative
The Pharmaceutical Society of Japan
Start Page
419
End Page
424
ISSN
00316903
NCID
AN00284903
Content Type
Journal Article
language
日本語
Copyright Holders
日本薬学会
File Version
publisher
Refereed
True
DOI
PubMed ID
Web of Science KeyUT