start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=神経性血圧調節に及ぼす高血糖および高インスリンの影響に関する循環薬理学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=藤原弘喜 kn-aut-sei=藤原 kn-aut-mei=弘喜 aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=細田美穂 kn-aut-sei=細田 kn-aut-mei=美穂 aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=日野隼人 kn-aut-sei=日野 kn-aut-mei=隼人 aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=平井和浩 kn-aut-sei=平井 kn-aut-mei=和浩 aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=岡本和明 kn-aut-sei=岡本 kn-aut-mei=和明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金? kn-aut-sei=金 kn-aut-mei=? aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木志真 kn-aut-sei=高木 kn-aut-mei=志真 aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=日本新薬株式会社創薬研究所 affil-num=9 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=419 end-page=424 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of postprandial hyperglycemia and hyperinsulinemia on vascular responsiveness kn-title=食後高血糖が血管反応性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent clinical studies demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension. Therefore, we investigated influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. Changes in vascular responses to spinal cord stimulation (SCS) and intravenous bolus injections of noradrenaline, angiotensin II, calcitonin generelated peptide (CGRP), acetylcholine and sodium nitroprusside (SNP) were studied by infusing various concentration of glucose or insulin. Continuous glucose infusion, which increased both blood glucose and serum insulin levels, significantly augmented adrenergic nerve-mediated pressor responses to SCS without affecting injection of pressor responses to noradrenaline or angiotensin II. In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP. In pithed rats treated with octreotide, which increased blood glucose without increasing serum insulin levels, glucose infusion caused only significant augmentation of adrenergic nervemediated pressor responses. Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemic, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses. The present results suggest that acute hyperglycemia and hyperinsulinemia increases adrenergic nerve-mediated vasoconstriction, which is partly associated with the blunted CGRPergic nerve function, and that plasma insulin concentration associated with hyperglycemia may be responsible for alteration of neuronal vascular regulation. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=3 ORCID= en-aut-name=YamawakiKosuke en-aut-sei=Yamawaki en-aut-mei=Kosuke kn-aut-name=山脇康佑 kn-aut-sei=山脇 kn-aut-mei=康佑 aut-affil-num=4 ORCID= en-aut-name=MiyashitaSatoko en-aut-sei=Miyashita en-aut-mei=Satoko kn-aut-name=宮下智子 kn-aut-sei=宮下 kn-aut-mei=智子 aut-affil-num=5 ORCID= en-aut-name=YabumaeNana en-aut-sei=Yabumae en-aut-mei=Nana kn-aut-name=藪前奈々 kn-aut-sei=藪前 kn-aut-mei=奈々 aut-affil-num=6 ORCID= en-aut-name=TakayamaFusako en-aut-sei=Takayama en-aut-mei=Fusako kn-aut-name=高山房子 kn-aut-sei=高山 kn-aut-mei=房子 aut-affil-num=7 ORCID= en-aut-name=MioMitsunobu en-aut-sei=Mio en-aut-mei=Mitsunobu kn-aut-name=見尾光庸 kn-aut-sei=見尾 kn-aut-mei=光庸 aut-affil-num=8 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬(株)創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=就実大学薬学部薬効解析学分野 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=hyperglycemia kn-keyword=hyperglycemia en-keyword=hyperinsulinemia kn-keyword=hyperinsulinemia en-keyword=Calcitonin gene-related peptide nerve kn-keyword=Calcitonin gene-related peptide nerve END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=12 article-no= start-page=2065 end-page=2073 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of propolis on insulin resistance in fructose-drinking rats kn-title=フルクトース負荷インスリン抵抗性モデル(ラット)におけるPropolisによるインスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300mg/kg, p. o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=KoayamaToshihiro en-aut-sei=Koayama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=3 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name=合田光寛 kn-aut-sei=合田 kn-aut-mei=光寛 aut-affil-num=4 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=5 ORCID= en-aut-name=DoiShima en-aut-sei=Doi en-aut-mei=Shima kn-aut-name=土井志真 kn-aut-sei=土井 kn-aut-mei=志真 aut-affil-num=6 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=fructose-drinking rat kn-keyword=fructose-drinking rat en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=periarterial nerve function kn-keyword=periarterial nerve function END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=11 article-no= start-page=2103 end-page=2107 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20081101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Royal jelly ameliorates insulin resistance in fructose-drinking rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name=合田光寛 kn-aut-sei=合田 kn-aut-mei=光寛 aut-affil-num=3 ORCID= en-aut-name=KoyamaToshihiro en-aut-sei=Koyama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=4 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=5 ORCID= en-aut-name=JinXin en-aut-sei=Jin en-aut-mei=Xin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=Takada-DoiShima en-aut-sei=Takada-Doi en-aut-mei=Shima kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=royal jelly kn-keyword=royal jelly en-keyword=fructose-drinking rat kn-keyword=fructose-drinking rat en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=periarterial nerve function kn-keyword=periarterial nerve function END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=4 article-no= start-page=1027 end-page=1033 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=2014 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Utility of simple suspension method compared to loss of drug using crushing method on tube administration kn-title=粉砕法による経管投与における薬剤量損失に対する簡易懸濁法の有用性についての検討 en-subtitle= kn-subtitle= en-abstract=Objective: In the past, a conventional crushing method was used for the administration of tablets or capsules by tube in patients with dysphagia. However, this method has several problems, such as a loss of the drug amount and tube clogging. Recently, tube administration by a simple suspension method was developed to solve these problems in the conventional crushing method. Methods: In the present study, we investigated to what extent the dosage amount is lost using the simple suspension method compared to crushing method, employing 5 drugs which are frequently administered by tube in Okayama University Hospital. Results: Drug weights of the 5 agents decreased by 70 〜 90% in the grinding and packaging processes because of drug adhesion to the mortar, packaging machine, and drug package paper. The suspension of all drugs using the simple suspension method was uniform, while only the suspension of Warfarin? ground using the crushing method was shown to be showed inhomogeneous, which is expected to lead to a loss of drug. The drug content on assuming clinical a setting after tube passage was compared between the two methods. The recovery of warfarin?, characterized as unstable using the crushing method, was nearly 50%, but loss was prevented by 80% with the use of bags of medicine. For the simple suspension method, the recovery of warfarin? was almost 100%. Conclusion: The results of this study suggest that the simple suspension method is particularly effective for the tube administration of drugs characterized as unstable. kn-abstract=【目的】従来の薬剤経管投与法である粉砕法は薬効の減少につながる薬剤量の損失が指摘されている。そこで粉砕法による薬剤量損失に対する簡易懸濁法の有用性について検討した。 【方法】頻繁に粉砕指示がなされる5種類の薬剤を用いて粉砕・分包による薬物含量減少、薬剤調製時の懸濁性および実際の経管投与を想定した薬物含量について2つの方法を比較した。 【結果】薬剤を粉砕・分包するとそれぞれの薬物含量は減少した。またワーファリン?錠を粉砕して水に溶解すると完全には懸濁せず、小さな塊が生じたが、簡易懸濁法では均一に懸濁した。ワーファリン?錠の経管投与を想定した実験において粉砕法では薬物含量が大幅に減少したが、簡易懸濁法では、ほとんど損失が認められなかった。【結論】簡易懸濁法は粉砕法に比べて薬剤損失の面で有用性が高いことが示唆され、ワーファリン?錠のように安定性が悪い薬剤では特に適正な薬物投与に貢献出来ると考えられる。 en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=KoyamaToshihiro en-aut-sei=Koyama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=2 ORCID= en-aut-name=AibaTetsuya en-aut-sei=Aiba en-aut-mei=Tetsuya kn-aut-name=合葉哲也 kn-aut-sei=合葉 kn-aut-mei=哲也 aut-affil-num=3 ORCID= en-aut-name=AmanoManabu en-aut-sei=Amano en-aut-mei=Manabu kn-aut-name=天野学 kn-aut-sei=天野 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=AndoTetsuaki en-aut-sei=Ando en-aut-mei=Tetsuaki kn-aut-name=安藤哲信 kn-aut-sei=安藤 kn-aut-mei=哲信 aut-affil-num=5 ORCID= en-aut-name=KurataNaomi en-aut-sei=Kurata en-aut-mei=Naomi kn-aut-name=倉田なおみ kn-aut-sei=倉田 kn-aut-mei=なおみ aut-affil-num=6 ORCID= en-aut-name=NawaHideki en-aut-sei=Nawa en-aut-mei=Hideki kn-aut-name=名和秀起 kn-aut-sei=名和 kn-aut-mei=秀起 aut-affil-num=7 ORCID= en-aut-name=NakuraHironori en-aut-sei=Nakura en-aut-mei=Hironori kn-aut-name=名倉弘哲 kn-aut-sei=名倉 kn-aut-mei=弘哲 aut-affil-num=8 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=9 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 affil-num=4 en-affil= kn-affil=兵庫医療大学 薬学部 affil-num=5 en-affil= kn-affil=吉備高原ルミエール病院 薬剤科 affil-num=6 en-affil= kn-affil=昭和大学 薬学部 affil-num=7 en-affil= kn-affil=岡山大学病院 薬剤部 affil-num=8 en-affil= kn-affil=岡山大学大学院 医歯薬学総合研究科 affil-num=9 en-affil= kn-affil=岡山大学病院 薬剤部 affil-num=10 en-affil= kn-affil=岡山大学病院 薬剤部 en-keyword=簡易懸濁法 (simple suspension method) kn-keyword=簡易懸濁法 (simple suspension method) en-keyword=経管投与 (tube administration) kn-keyword=経管投与 (tube administration) en-keyword=薬剤量の損失 (loss of drug amount) kn-keyword=薬剤量の損失 (loss of drug amount) END