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ID 57940
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Ikeda, Tomoka Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Gion, Yuka Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Sato, Yasuharu Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Abstract
Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous regression. Histologically, EBVMCUs are characterized by the proliferation of EBV-positive, variable-sized, atypical B-cells. According to conventional histopathologic criteria, EBVMCUs may diagnosed as lymphomas. However, EBVMCUs are recognized as pseudomalignant lesions because they spontaneously regress without anti-cancer treatment. Therefore, overtreatment must be carefully avoided and multilateral differentiation is important. In this article, we reviewed previously reported EBVMCUs focusing on their clinical and pathological aspects in comparison with other EBV-positive B-cell neoplasms.
Keywords
EBV-positive mucocutaneous ulcer
clinical features
immunosuppression
pathological features
Published Date
2019-06-28
Publication Title
Journal of Clinical and Experimental Hematopathology
Volume
volume59
Issue
issue2
Publisher
Japanese Society for Lymphoratic Tissue Research
Start Page
64
End Page
6471
ISSN
1346-4280
NCID
AA11556796
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
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publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3960/jslrt.18039
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Tomoka Ikeda, Yuka Gion, Tadashi Yoshino, Yasuharu Sato, A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects, Journal of Clinical and Experimental Hematopathology, 2019, Volume 59, Issue 2, Pages 64-71, Released June 28, 2019, Online ISSN 1880-9952, Print ISSN 1346-4280, https://doi.org/10.3960/jslrt.18039