ID | 53648 |
FullText URL | |
Author |
Kyotaro, Ohno
Yasuharu, Sato
Koh-ichi, Ohshima
Katsuyoshi, Takata
Tomoko, Miyata-Takata
Mai, Takeuchi
Yuka, Gion
Tomoyasu, Tachibana
Yorihisa, Orita
Toshihiro, Ito
Steven, H. Swerdlow
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Abstract | We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.
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Note | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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Published Date | 2015
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Publication Title |
Scientific Reports
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Volume | volume5
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Publisher | Nature Publishing Group
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Start Page | 13539
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ISSN | 2045-2322
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Content Type |
Journal Article
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Official Url | http://dx.doi.org/10.1038/srep13539
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language |
English
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Copyright Holders | © 2015 Nature Publishing Group
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |