Title Alternative Natural history and pathogenicity of herpesviruses
Author Yamada, Masao|
Keywords ヘルペスウイルス 自然史 病態 潜伏感染 再活性化
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 13
End Page 17
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.13
language 日本語
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.13
NAID 130007840316
FullText URL JVMS81_8_1191.pdf
Author Ogawa, Hirohito| Hirayama, Haruko| Tanaka, Satsuki| Yata, Norio| Namba, Hikaru| Yamashita, Nobuko| Yonemitsu, Kenzo| Maeda, Ken| Mominoki, Katsumi| Yamada, Masao|
Keywords animal experimental facility domestic pig hepatitis E virus zoonosis
Published Date 2019-08-24
Publication Title Journal of Veterinary Medical Science
Volume volume81
Issue issue8
Publisher The Japanese Society of Veterinary Science
Start Page 1191
End Page 1196
ISSN 0916-7250
NCID AA10796138
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders ©2019 The Japanese Society of Veterinary Science
File Version publisher
PubMed ID 31281141
DOI 10.1292/jvms.19-0086
Web of Science KeyUT 000492854900021
Related Url isVersionOf https://doi.org/10.1292/jvms.19-0086
Title Alternative The 56th Annual Meeting of the Japanese Society for Clinical Virology
FullText URL 127_261.pdf
Author Yamada, Masao|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 261
End Page 262
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.261
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.261
NAID 130005116805
Author Noda, Yohei| Nishizaki, Kazunori| Yoshinobu, Junko| Orita, Yorihisa| Tsujigiwa, Hidetsugu| Yamada, Masao|
Published Date 2013-09
Publication Title Acta Oto-laryngologica
Volume volume133
Issue issue9
Content Type Journal Article
Author Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| Yodoi, Junji| Morishima, Tsuneo|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi|
Published Date 2013-01
Publication Title Critical Care Medicine
Volume volume41
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/32214
FullText URL fulltext.pdf
Author Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
Abstract <p>In order to elucidate the mechanism of latent infection of herpes simplex virus (HSV), reactivatable latency of three avirulent strains (SKO-1B, -GCr Miyama, SKa) of HSV type 1 was comparatively examined in a mouse latency model. The SKO-1B strain showed high rate of virus reactivation from explanted trigeminal ganglia without n-butyrate enhancement, while the other two strains showed a very low rate of virus reactivation in the absence of n-butyrate. In the presence of n-butyrate, however, the rate of the -GCr Miyama strain jumped to a comparable level with that of SKO-1B, although the rate of SKa remained at a low level. A more precise follow-up experiment changing the virus dose highlighted the difference of the ability to reactivate from the latent state between SKO-1B and -GCr Miyama. Virus titer in trigeminal ganglia during acute phase, infectivity to cell lines of neural origin, and susceptibility to acyclovir and phosphonoacetate were assayed to know the reasons for the variation in the ability of reactivatable latency among these strains. It was concluded that the reduced infectivity to neural cells, and limited ability of reactivatable latency shown by the SKa strain could mainly be attributed to the deficiency of thymidine kinase activity.&#60;/P&#62;</p>
Keywords herpes simplex virus type 1 neurovirulence latency reactivation n-butyrate
Amo Type Article
Published Date 1991-02
Publication Title Acta Medica Okayama
Volume volume45
Issue issue1
Publisher Okayama University Medical School
Start Page 43
End Page 47
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1648298
Web of Science KeyUT A1991FA75000006
JaLCDOI 10.18926/AMO/32190
FullText URL fulltext.pdf
Author Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
Abstract <p>Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.&#60;/P&#62;</p>
Keywords herpes simplex virus type 1 neurovirulence latency reactivation
Amo Type Article
Published Date 1991-04
Publication Title Acta Medica Okayama
Volume volume45
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 121
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1651044
Web of Science KeyUT A1991FL60800008
JaLCDOI 10.18926/AMO/32097
FullText URL fulltext.pdf
Author Koirala, Tirtha Raj| Hayashi, Kazuhiko| Jin, Zaishun| Onoda, Sachiyo| Tanaka, Takehiro| Oda, Wakako| Ichimura, Koichi| Ohara, Nobuya| Oka, Takashi| Yamada, Masao| Yoshino, Tadashi|
Abstract <p>Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 approximately x 10) titers decreased during the first 1-2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of x 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion-related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings.</p>
Keywords ?Epstein-Barr virus(EBV) rabbit lymphoproliferative diseases blood transfusion
Amo Type Article
Published Date 2004-04
Publication Title Acta Medica Okayama
Volume volume58
Issue issue2
Publisher Okayama University Medical School
Start Page 67
End Page 74
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15255507
Web of Science KeyUT 000221043700002
Author 山田 雅夫|
Published Date 2001-04-28
Publication Title 岡山医学会雑誌
Volume volume113
Issue issue1
Content Type Journal Article
Author 山田 雅夫|
Published Date 1983-03-31
Publication Title
Content Type Thesis or Dissertation