JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Published Date 2020-08
Publication Title Acta Medica Okayama
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL SR9_1_11934.pdf
Author Takahara, Masahiro| Takaki, Akinobu| Hiraoka, Sakiko| Adach, Takuya| Shimomura, Yasuyuki| Matsushita, Hiroshi| Nguyen Tien Thi Thuy| Koike, Kazuko| Ikeda, Airi| Takashima, Shiho| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Sugihara, Yusaku| Harada, Keita| Eikawa, Shingo| Morita, Hidetoshi| Udono, Heiichiro| Okada, Hiroyuki|
Published Date 2019-8-15
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 11934
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version Publisher
PubMed ID 31417110
DOI 10.1038/s41598-019-48331-w
Web of Science KeyUT 000480680800048
Related Url isVersionOf https://doi.org/10.1038/s41598-019-48331-w