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ID 58545
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Author
Murai, Masahito Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Yamamoto, Masaki Graduate School of Natural Science and Technology, Okayama University
Takai, Kazuhiko Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
An operationally simple and direct rhenium-catalyzed ortho-alkenylation (C-alkenylation) of unprotected phenols with alkynes was developed. The protocol provided ortho-alkenylphenols exclusively, and formation of para- or multiply alkenylated phenols and hydrophenoxylation (O-alkenylation) products were not observed. The [3 + 2 + 1] cycloaddition of phenols and two alkynes via ortho-alkenylation was also demonstrated, in which the alkynes functioned as both two- and one-carbon units. These reactions proceeded with readily available starting materials under neutral conditions without additional ligands.
Keywords
anti-markovnikov addition
intramolecular hydroarylation
oxidative annulation
gold
hydrophenoxylation
construction
cyclization
vinylation
alkenes
Published Date
2019-04-18
Publication Title
Organic Letters
Volume
volume21
Issue
issue9
Publisher
American Chemical Society
Start Page
3441
End Page
3445
ISSN
15237060
NCID
AA11347843
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1021/acs.orglett.9b01214
Funder Name
Ministry of Education, Culture, Sports, Science and Technology
助成番号
18H03911