JaLCDOI 10.18926/AMO/60799
FullText URL 74_5_401.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi|
Abstract Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
Keywords differentiated thyroid carcinoma juvenile children
Amo Type Original Article
Published Date 2020-10
Publication Title Acta Medica Okayama
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 406
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106695
FullText URL fulltext.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Doihara, Hiroyoshi|
Keywords Breast cancer metastatic stage IV local therapy locoregional therapy surgery survival
Published Date 2020-08
Publication Title Translational Cancer Research
Volume volume9
Issue issue8
Publisher AME Publishing Co.
Start Page 5102
End Page 5107
ISSN 2218-676X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Translational Cancer Research. All rights reserved.
File Version publisher
DOI 10.21037/tcr.2020.01.60
Web of Science KeyUT 000562138400067
Related Url isVersionOf https://doi.org/10.21037/tcr.2020.01.60
Author Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi|
Keywords Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance
Note This fulltext is available in Jul. 2021.|
Published Date 2020-08-27
Publication Title Biochemical and Biophysical Research Communications
Volume volume529
Issue issue3
Publisher Academic Press
Start Page 760
End Page 765
ISSN 0006-291X
NCID AA00564395
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32736704
DOI 10.1016/j.bbrc.2020.06.077
Web of Science KeyUT 000555780500037
Related Url iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077
FullText URL CCP_fulltext.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Keywords Breast cancer Metformin Preoperative Tils CD8 PD-L1
Published Date 2020-06-12
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume86 volume86
Issue issue1 issue1
Publisher Springer
Start Page 55 55
End Page 63 63
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders ©Author(s)
File Version Publisher
PubMed ID 32533334
DOI 10.1007/s00280-020-04092-2
Web of Science KeyUT 000539841500002
Related Url isVersionOf https://doi.org/10.1007/s00280-020-04092-2
FullText URL fulltext.pdf
Author Shien, Tadahiko|
Published Date 2019-03
Publication Title Translational Cancer Research
Volume volume8
Issue issueSuppl. 2
Publisher AME Publishing
Start Page S118
End Page S119
ISSN 2218-676X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.21037/tcr.2018.11.19
Related Url isVersionOf https://doi.org/10.21037/tcr.2018.11.19
FullText URL fulltext.pdf
Author Shien, Tadahiko| Iwata, Hiroji|
Keywords breast cancer adjuvant neoadjuvant
Note This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record TTadahiko Shien, Hiroji Iwata, Adjuvant and neoadjuvant therapy for breast cancer, Japanese Journal of Clinical Oncology, Volume 50, Issue 3, March 2020, Pages 225–229 is available online at: https://doi.org/10.1093/jjco/hyz213.|
Published Date 2020-01-28
Publication Title Japanese Journal of Clinical Oncology
Volume volume50
Issue issue3
Publisher Oxford University Press
Start Page 225
End Page 229
ISSN 0368-2811
NCID AA00690866
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2020 Oxford University Press
File Version author
PubMed ID 32147701
DOI 10.1093/jjco/hyz213
Web of Science KeyUT 000536439500001
Related Url isVersionOf https://doi.org/10.1093/jjco/hyz213
Author Iwamoto, Takayuki| Fujisawa, Tomomi| Shien, Tadahiko| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Takao, Shintaro| Nishimura, Reiki| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| aira, Naruto|
Keywords Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title Breast Cancer
Publisher Springer
ISSN 13406868
NCID AA1103354X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32394413
DOI 10.1007/s12282-020-01095-y
Web of Science KeyUT 000531780600002
Related Url isVersionOf https://doi.org/10.1007/s12282-020-01095-y
FullText URL fulltext.pdf
Author Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi|
Keywords breast cancer drug resistance lung cancer neratinib YES1
Published Date 2019-12-19
Publication Title Cancer Science
Volume volume111
Issue issue3
Publisher Wiley
Start Page 849
End Page 856
ISSN 1347-9032
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31856375
DOI 10.1111/cas.14289
Web of Science KeyUT 000507433400001
Related Url isVersionOf https://doi.org/10.1111/cas.14289
FullText URL fulltext.pdf
Author Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki