FullText URL fulltext.pdf
Author Tsukioki, Takahiro| Takata, Nozomu| Dennis, Saya R.| Terata, Kaori| Sagara, Yasuaki| Sakai, Takehiko| Takayama, Shin| Kitagawa, Dai| Kikawa, Yuichiro| Takahashi, Yuko| Iwatani, Tsuguo| Hara, Fumikata| Fujisawa, Tomomi| Shien, Tadahiko|
Keywords Breast cancer FACT-B FACT-B+4 QOL
Note The version of record of this article, first published in Breast Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12282-025-01701-x|
Published Date 2025-05-08
Publication Title Breast Cancer
Volume volume32
Issue issue4
Publisher Springer Science and Business Media LLC
Start Page 773
End Page 782
ISSN 1340-6868
NCID AA1103354X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40338515
DOI 10.1007/s12282-025-01701-x
Web of Science KeyUT 001483857300001
Related Url isVersionOf https://doi.org/10.1007/s12282-025-01701-x
FullText URL fulltext20250507-01.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Shien, Tadahiko| Muraoka, Atsushi| Doihara, Hiroyoshi|
Keywords breast cancer chemotherapy choroidal metastasis estrogen receptor her2 immunostaining invasive ductal carcinoma ki-67 progesterone receptor radiation
Published Date 2025-05-04
Publication Title Cureus
Volume volume17
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page e83484
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2025 Matsuo et al.
File Version publisher
PubMed ID 40470417
DOI 10.7759/cureus.83484
Related Url isVersionOf https://doi.org/10.7759/cureus.83484
FullText URL fulltext.pdf
Author Mamori, Tomoka| Tanioka, Maki| Takada, Kenji| Hamano, Hirofumi| Tsukioki, Takahiro| Takahashi, Yuko| Iwatani, Tsuguo| Shien, Tadahiko| Toyooka, Shinichi|
Note The version of record of this article, first published in BioDrugs, is available online at Publisher’s website: http://dx.doi.org/10.1007/s40259-024-00686-x|
Published Date 2024-10-16
Publication Title BioDrugs
Volume volume39
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 131
End Page 142
ISSN 1173-8804
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39412713
DOI 10.1007/s40259-024-00686-x
Web of Science KeyUT 001333384600001
Related Url isVersionOf https://doi.org/10.1007/s40259-024-00686-x
FullText URL fulltext.pdf
Author Shien, Tadahiko| Tsuda, Hitoshi| Sasaki, Keita| Mizusawa, Junki| Akiyama, Futoshi| Kurosumi, Masafumi| Sawaki, Masataka| Tamura, Nobuko| Tanaka, Kiyo| Kogawa, Takahiro| Takahashi, Mina| Hayashi, Naoki| Mukai, Hirofumi| Masuda, Norikazu| Hara, Fumikata| Iwata, Hiroji|
Keywords Breast cancer Neoadjuvant chemoradiotherapy Pathological therapeutic effect Specimen sampling method
Note The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-024-07408-5|
Published Date 2024-06-27
Publication Title Breast Cancer Research and Treatment
Volume volume208
Publisher Springer Science and Business Media LLC
Start Page 145-
End Page 154
ISSN 0167-6806
NCID AA10623184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38935214
DOI 10.1007/s10549-024-07408-5
Web of Science KeyUT 001256954600001
Related Url isVersionOf https://doi.org/10.1007/s10549-024-07408-5
FullText URL fulltext.pdf
Author Nakamoto, Shogo| Shien, Tadahiko| Iwamoto, Takayuki| Kubo, Shinichiro| Yamamoto, Mari| Yamashita, Tetsumasa| Kuwahara, Chihiro| Ikeda, Masahiko|
Published Date 2024-04-30
Publication Title Scientific Reports
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 9869
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38684839
DOI 10.1038/s41598-024-60101-x
Web of Science KeyUT 001211286800006
Related Url isVersionOf https://doi.org/10.1038/s41598-024-60101-x
FullText URL fulltext.pdf
Author Swe, Hnin‐Wint‐Wint| Fujisawa, Masayoshi| Ohara, Toshiaki| Komatsubara, Yu| Yoshimura, Teizo| Shien, Tadahiko| Matsukawa, Akihiro|
Keywords angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
Published Date 2024-05-31
Publication Title Pathology International
Volume volume74
Issue issue7
Publisher Wiley
Start Page 394
End Page 407
ISSN 1320-5463
NCID AA10984364
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 38818885
DOI 10.1111/pin.13442
Web of Science KeyUT 001235649700001
Related Url isVersionOf https://doi.org/10.1111/pin.13442
FullText URL fulltext.pdf
Author Otani, Yusuke| Katayama, Haruyoshi| Zhu, Yidan| Huang, Rongsheng| Shigehira, Takafumi| Shien, Kazuhiko| Suzawa, Ken| Yamamoto, Hiromasa| Shien, Tadahiko| Toyooka, Shinichi| Fujimura, Atsushi|
Keywords adrenaline cancer-associated Schwann cells doublecortin microenvironment YAP/TAZ
Published Date 2024-04-27
Publication Title Cancer Science
Volume volume115
Issue issue7
Publisher Wiley
Start Page 2333
End Page 2345
ISSN 1347-9032
NCID AA11808050
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38676373
DOI 10.1111/cas.16164
Web of Science KeyUT 001208622800001
Related Url isVersionOf https://doi.org/10.1111/cas.16164
FullText URL fulltext.pdf
Author Sasada, Shinsuke| Kondo, Naoto| Hashimoto, Hiroya| Takahashi, Yuko| Terata, Kaori| Kida, Kumiko| Sagara, Yasuaki| Ueno, Takayuki| Anan, Keisei| Suto, Akihiko| Kanbayashi, Chizuko| Takahashi, Mina| Nakamura, Rikiya| Ishiba, Toshiyuki| Tsuneizumi, Michiko| Nishimura, Seiichiro| Naito, Yoichi| Hara, Fumikata| Shien, Tadahiko| Iwata, Hiroji|
Keywords Breast cancer T1a/b Endocrine therapy Estrogen receptor Prognosis
Note The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-023-07097-6|
Published Date 2023-09-09
Publication Title Breast Cancer Research and Treatment
Volume volume202
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 473
End Page 483
ISSN 0167-6806
NCID AA10623184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37688665
DOI 10.1007/s10549-023-07097-6
Web of Science KeyUT 001065105700004
Related Url isVersionOf https://doi.org/10.1007/s10549-023-07097-6
JaLCDOI 10.18926/AMO/66676
FullText URL 78_1_089.pdf
Author Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki|
Abstract We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis.
Keywords breast cancer ectopic breast cancer axillary lymph node
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 89
End Page 93
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419320
Web of Science KeyUT 001204421300001
JaLCDOI 10.18926/AMO/66666
FullText URL 78_1_015.pdf
Author Maeda, Reina| Shien, Tadahiko| Takahashi, Mina| Kawada, Kengo| Kajiwara, Yukiko| Kubo, Shinichiro| Takabatake, Daisuke| Ohtani, Shoichiro| Matsuoka, Kinya| Hikino, Hajime| Ogasawara, Yutaka| Taira, Naruto| Osumi, Shozo| Ikeda, Masahiko| Doihara, Hiroyoshi|
Abstract While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
Keywords oligometastasis breast cancer lung metastasectomy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 15
End Page 20
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419310
Web of Science KeyUT 001203658200008
FullText URL fulltext.pdf
Author Tsukioki, Takahiro| Khan, Seema A.| Shien, Tadahiko|
Keywords Breast cancer Prevention Risk reduction mastectomy Chemoprevention Methylation
Note The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00287-0|
Published Date 2023-12-12
Publication Title Genes and Environment
Volume volume45
Issue issue1
Publisher BMC
Start Page 35
ISSN 1880-7046
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 38082340
DOI 10.1186/s41021-023-00287-0
Web of Science KeyUT 001121724100001
Related Url isVersionOf https://doi.org/10.1186/s41021-023-00287-0
JaLCDOI 10.18926/AMO/64356
FullText URL 77_1_11.pdf
Author Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro|
Abstract The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction.
Keywords breast reconstruction mastectomy brassiere professional bra fitter
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 11
End Page 19
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849141
Web of Science KeyUT 000953663800002
FullText URL fulltext.pdf
Author Ochi, Kosuke| Suzawa, Ken| Thu, Yin Min| Takatsu, Fumiaki| Tsudaka, Shimpei| Zhu, Yidan| Nakata, Kentaro| Takeda, Tatsuaki| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Okamoto, Yoshiharu| Tomida, Shuta| Toyooka, Shinichi|
Keywords cancer-associated fibroblast drug resistance tranilast
Published Date 2022-07-24
Publication Title Cancer Science
Volume volume2022
Publisher Wiley
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35871750
DOI 10.1111/cas.15502
Web of Science KeyUT 000840374000001
Related Url isVersionOf https://doi.org/10.1111/cas.15502
FullText URL fulltext.pdf
Author Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Keywords breast cancer YES1 T-DM1 dasatinib drug resistance
Published Date 2021-11-26
Publication Title International Journal Of Molecular Sciences
Volume volume22
Issue issue23
Publisher MDPI
Start Page 12809
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34884609
DOI 10.3390/ijms222312809
Web of Science KeyUT 000735641400001
Related Url isVersionOf https://doi.org/10.3390/ijms222312809
JaLCDOI 10.18926/AMO/60799
FullText URL 74_5_401.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi|
Abstract Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
Keywords differentiated thyroid carcinoma juvenile children
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 406
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106695
Web of Science KeyUT 000581970100004
NAID 120006892925
FullText URL fulltext.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Doihara, Hiroyoshi|
Keywords Breast cancer metastatic stage IV local therapy locoregional therapy surgery survival
Published Date 2020-08
Publication Title Translational Cancer Research
Volume volume9
Issue issue8
Publisher AME Publishing Co.
Start Page 5102
End Page 5107
ISSN 2218-676X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Translational Cancer Research. All rights reserved.
File Version publisher
DOI 10.21037/tcr.2020.01.60
Web of Science KeyUT 000562138400067
Related Url isVersionOf https://doi.org/10.21037/tcr.2020.01.60
FullText URL fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx
Author Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi|
Keywords Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance
Note This fulltext is available in Jul. 2021.|
Published Date 2020-08-27
Publication Title Biochemical and Biophysical Research Communications
Volume volume529
Issue issue3
Publisher Academic Press
Start Page 760
End Page 765
ISSN 0006-291X
NCID AA00564395
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32736704
DOI 10.1016/j.bbrc.2020.06.077
Web of Science KeyUT 000555780500037
Related Url iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077
FullText URL CCP_fulltext.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Keywords Breast cancer Metformin Preoperative Tils CD8 PD-L1
Published Date 2020-06-12
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume86 volume86
Issue issue1 issue1
Publisher Springer
Start Page 55 55
End Page 63 63
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©Author(s)
File Version publisher
PubMed ID 32533334
DOI 10.1007/s00280-020-04092-2
Web of Science KeyUT 000539841500002
Related Url isVersionOf https://doi.org/10.1007/s00280-020-04092-2
FullText URL fulltext.pdf
Author Shien, Tadahiko|
Published Date 2019-03
Publication Title Translational Cancer Research
Volume volume8
Issue issueSuppl. 2
Publisher AME Publishing
Start Page S118
End Page S119
ISSN 2218-676X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.21037/tcr.2018.11.19
Related Url isVersionOf https://doi.org/10.21037/tcr.2018.11.19
FullText URL fulltext.pdf
Author Shien, Tadahiko| Iwata, Hiroji|
Keywords breast cancer adjuvant neoadjuvant
Note This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record TTadahiko Shien, Hiroji Iwata, Adjuvant and neoadjuvant therapy for breast cancer, Japanese Journal of Clinical Oncology, Volume 50, Issue 3, March 2020, Pages 225–229 is available online at: https://doi.org/10.1093/jjco/hyz213.|
Published Date 2020-01-28
Publication Title Japanese Journal of Clinical Oncology
Volume volume50
Issue issue3
Publisher Oxford University Press
Start Page 225
End Page 229
ISSN 0368-2811
NCID AA00690866
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2020 Oxford University Press
File Version author
PubMed ID 32147701
DOI 10.1093/jjco/hyz213
Web of Science KeyUT 000536439500001
Related Url isVersionOf https://doi.org/10.1093/jjco/hyz213