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ID 52032
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Author
Hayashi, Eiko
Tashiro, Yukie
Tachiyama, Yoshiro
Sawada-Kitamura, Seiko
Hiramatsu, Yasushi
Sugiguchi, Shun
Nose, Soichiro
Hirokawa, Mitsuyoshi
Ando, Midori
Abd Mader, Lamia
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients. generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not Included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD:20 Was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor gamma chain and/or alpha-beta chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered.
Keywords
Indolent PTCL
CD20
Ki-67
Memory T cell
Good prognosis
Published Date
2013-09
Publication Title
Human Pathology
Volume
volume44
Issue
issue9
Start Page
1927
End Page
1936
ISSN
0046-8177
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1016/j.humpath.2013.03.002
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51963
language
英語
Copyright Holders
(C) 2013 Published by Elsevier Inc. All rights reserved.
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author
Refereed
True
DOI
Web of Sience KeyUT