FullText URL fulltext.pdf
Author Kanzaki, Yuki| Fujita, Hirofumi| Sato, Keita| Hosokawa, Mio| Matsumae, Hiroshi| Shiraga, Fumio| Morizane, Yuki| Ohuchi, Hideyo|
Keywords Kir7.1 KCNJ13 human-induced pluripotent cells retinal pigment epithelium phagocytosis
Published Date 2020-05
Publication Title Investigative Ophthalmology & Visual Science
Volume volume61
Issue issue5
Publisher Association for Research in Vision and Ophthalmology
Start Page 38
ISSN 0146-0404
NCID AA00683736
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Copyright 2020 The Authors
File Version publisher
PubMed ID 32437550
DOI 10.1167/iovs.61.5.38
Web of Science KeyUT 000540905500039
Related Url isVersionOf https://doi.org/10.1167/iovs.61.5.38
FullText URL fulltext.pdf
Author Morisawa, Shin| Hamasaki, Ichiro| Shibata, Kiyo| Shimizu, Takehiro| Kono, Reika| Miyata, Manabu| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio|
Keywords Intermittent exotropia Postoperative exo-drift Recurrent exotropia Recession and resection procedure Strabismus surgery
Published Date 2020-06-05
Publication Title BMC Ophthalmology
Volume volume20
Issue issue1
Publisher BMC
ISSN 1471-2415
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32503457
DOI 10.1186/s12886-020-01484-z
Web of Science KeyUT 000540232800002
Related Url isVersionOf https://doi.org/10.1186/s12886-020-01484-z
JaLCDOI 10.18926/AMO/59956
FullText URL 74_3_229.pdf
Author Shibata, Kiyo| Hamasaki, Ichiro| Toshima, Shinji| Shimizu, Takehiro| Kono, Reika| Miyata, Manabu| Morisawa, Shin| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio|
Abstract The purpose of this study was to derive new formulas to provide an optimal surgical procedure and optimal amount of recession-resection (RR) surgery in intermittent exotropia (IXT) with a disparity in angle of deviation depending on the fixation distance. The records of 117 consecutive patients with IXT who underwent RR surgery between March 2008 and December 2011 at Okayama University Hospital were retrospectively examined. Multivariable linear regression analysis was performed using the observed corrective angle of deviation at distance or near fixation as the dependent variable, and amounts of lateral rectus muscle (LR) recession (mm) and medial rectus muscle (MR) resection, and age at surgery (years) as independent variables. Two simultaneous formulas were derived: corrective angle of deviation at distance fixation (°)=1.8×recession (mm)+1.6× resection (mm)+0.15×age (years)–6.6, and corrective angle at near fixation (°)=1.5×recession (mm)+1.7× resection (mm)+0.18×age (years)–3.8. Comparisons of coefficient values of the formulas between distance and near fixation revealed that LR recession was more affected by the corrective angle in distance than near fixation. MR resection was more affected at near than distance fixation. We found that our new formulas estimated the appropriate amount of unilateral RR surgery.
Keywords surgical amount intermittent exotropia recession and resection procedure strabismus surgery recurrent exotropia
Amo Type Original Article
Published Date 2020-06
Publication Title Acta Medica Okayama
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 229
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577021
FullText URL fulltext.pdf tables.pdf Fig1.tif Fig2.jpg Fig3.tif Fig4.tif Fig5.tif
Author Kono, Reika| Ohtsuki, Hiroshi| Kishimoto, Fumiko| Hamasaki, Ichiro| Morizane, Yuki| Shiraga, Fumio|
Keywords age-related distance esotropia esotropia high myopia orbital pulley sagging eye syndrome
Published Date 2019-01-22
Publication Title Graefe's Archive for Clinical and Experimental Ophthalmology
Volume volume257
Publisher Springer
Start Page 662
End Page 662
ISSN 0721832X
NCID AA11623893
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30671656
DOI 10.1007/s00417-019-04250-0
Web of Science KeyUT 000459788800025
Related Url isVersionOf https://doi.org/10.1007/s00417-019-04250-0
JaLCDOI 10.18926/AMO/57716
FullText URL 73_6_517.pdf
Author Hosogi, Mika| Shiode, Yusuke| Morizane, Yuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Toshima, Shinji| Takahashi, Kosuke| Fujiwara, Atsushi| Shiraga, Fumio|
Abstract We investigated the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 2-year results of 32 eyes of 32 patients who underwent TAE to treat ME due to BRVO. The patients whose treatment interval extended to ≥ 12 weeks were switched to a pro re nata regimen (PRN). For the patients whose treatment interval was <12 weeks, TAE was continued. At 2 years, 10 eyes had required no additional injections after the initial treatment period [recurrence(−) group], whereas the other 22 eyes required additional treatment [recurrence(+) group]. Among the recurrence(+) patients, 11 eyes (34.4% of total) were eventually switched from TAE to PRN; the other 11 eyes (34.4%) continued TAE for 2 years. Visual acuity and central retinal thickness were significantly improved in both the recurrence(+) and (−) groups, and there was no significant betweengroup difference in visual acuity at 2 years. Univariate analyses revealed significant differences in visual acuity (p=0.004), age (p=0.014), and vessel occlusion site (p=0.018) between these groups. Our results suggest that TAE may be effective for BRVO patients with lower visual acuity, older age, and occlusion of a major vein.
Keywords branch retinal vein occlusion macular edema anti-vascular endothelial growth factor ranibizumab treat-and-extend regimen
Amo Type Original Article
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 517
End Page 522
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871334
Web of Science KeyUT 000503431400007
JaLCDOI 10.18926/AMO/57378
FullText URL 73_5_463.pdf
Author Shibata, Kiyo| Hamasaki, Ichiro| Shimizu, Takehiro| Kono, Reika| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio|
Abstract To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the “twist knot” and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p<0.001). The twist knot technique allowed easy sliding without the multifilament braided suture becoming frayed and a knot to be firmly fixed without slipping. However, if the 2 strings of the pole sutures exit from the sclera at 2 widely separated positions, the sliding noose may become slack. Therefore, the distance between the pole sutures should be small. The simple twist knot technique was found to be an effective approach following adjustable surgery of strabismus.
Keywords adjustable suture the new sliding noose method tensile strength strabismus surgery esotropia
Amo Type Case Report
Published Date 2019-10
Publication Title Acta Medica Okayama
Volume volume73
Issue issue5
Publisher Okayama University Medical School
Start Page 463
End Page 468
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31649374
Web of Science KeyUT 000491886600013
JaLCDOI 10.18926/AMO/55209
FullText URL 71_3_255.pdf
Author Kumase, Fumiaki| Morizane, Yuki| Kimura, Shuhei| Toshima, Shinji| Shiraga, Fumio|
Abstract  Parafoveal retinal holes (PRHs) are one of the complications that can occur after internal limiting membrane (ILM) peeling during macular surgery. Here we describe a patient in whom an exceptionally large PRH (1,069-μm dia.) was successfully closed by repeated autologous ILM transplantation.
Keywords autologous internal limiting membrane transplantation parafoveal retinal hole, macular surgery
Amo Type Case Report
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 257
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655946
JaLCDOI 10.18926/AMO/53678
FullText URL 69_5_313.pdf
Author Narita, Akiko| Seguchi, Jiro| Shiraga, Fumio|
Abstract Paecilomyces lilacinus (P. lilacinus) is a rare cause of fungal scleritis. We herein report a case of P. lilacinus-induced scleritis following bleb-associated endophthalmitis after trabeculectomy that was successfully treated with surgical excision of the affected sclera in combination with antifungal medication. An 85-year-old female underwent trabeculectomy of the left eye. A dellen formed in the corneal periphery due to limbal elevation of the filtering bleb and progressed to an infectious corneal ulcer, leading to blebitis. Eight days after the onset of blebitis, the patient was diagnosed with endophthalmitis, which resolved after vitrectomy. The growth of P. lilacinus was identified on swabs of the conjunctiva and the corneal specimen. Scleritis developed after the resolution of the endophthalmitis, and an early excision of the affected sclera, in addition to antifungal medication, resolved it completely. However, the scleritis recurred in a different region of the left eye. After 7 months of antifungal medication, the left eye showed no residual infection. When treating P. lilacinus-induced scleritis, surgical excision of the affected sclera has been shown to be an effective treatment strategy. Nevertheless, it is possible that the infection may recur in another part of the eyeball after the complete resolution of the primary lesion.
Keywords Paecilomyces lilacinus scleritis trabeculectomy
Amo Type Case Report
Published Date 2015-10
Publication Title Acta Medica Okayama
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 313
End Page 318
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490029
Web of Science KeyUT 000365519600008
JaLCDOI 10.18926/AMO/53028
FullText URL 68_6_379.pdf
Author Doi, Shinichiro| Kimura, Shuhei| Morizane, Yuki| Hosogi, Mika| Hosokawa, Mio| Shiode, Yusuke| Kawata, Tetsuhiro| Kondo, Eisei| Shiraga, Fumio|
Abstract We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted for 1 month. He also noted headache, nausea, and paresthesia in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. Optic disc edema and serous retinal detachment were present. Brain magnetic resonance imaging showed no intracranial abnormalities, while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, hepatosplenomegaly, M proteinemia, high blood VEGF levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in bone lesions were noted. From the above findings, the patient was diagnosed with POEMS syndrome. He received high-dose dexamethasone, thalidomide, and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of POEMS syndrome with ocular manifestation. If patients have optic disc edema in both eyes with no intracranial space-occupying lesion, POEMS syndrome should be considered in differential diagnosis, regardless of age.
Keywords POEMS syndrome serous retinal detachment VEGF
Amo Type Case Report
Published Date 2014-12
Publication Title Acta Medica Okayama
Volume volume68
Issue issue6
Publisher Okayama University Medical School
Start Page 379
End Page 383
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25519033
Web of Science KeyUT 000346882200009