| JaLCDOI | 10.18926/AMO/48569 |
|---|---|
| FullText URL | 66_3_285.pdf |
| Author | Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi| |
| Abstract | Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required. |
| Keywords | beta-blocker landiolol formalin pain behavior c-fos |
| Amo Type | Original Article |
| Published Date | 2012-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 289 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729110 |
| Web of Science KeyUT | 000305669700013 |
| FullText URL | NeurobiolDis_50_209.pdf |
|---|---|
| Author | Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Mori, Akiko| Michiue, Hiroyuki| Nishiki, Teiichi| Ohtsuka, Yoko| Matsui, Hideki| |
| Note | CACNA1A variants contribute to severity of seizures in Dravet syndrome| |
| Published Date | 2013-02 |
| Publication Title | Neurobiology of disease |
| Volume | volume50 |
| Publisher | Academic Press |
| Start Page | 209 |
| End Page | 217 |
| ISSN | 09699961 |
| NCID | AA11645502 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 23103419 |
| DOI | 10.1016/j.nbd.2012.10.016 |
| Web of Science KeyUT | 000313758100023 |
| Related Url | isVersionOf https://doi.org/10.1016/j.nbd.2012.10.016 |
| JaLCDOI | 10.18926/AMO/48262 |
|---|---|
| FullText URL | 66_2_119.pdf.pdf |
| Author | Oka, Hiroaki| Ouchida, Mamoru| Kondo, Takuya| Morita, Fumio| Shimizu, Kenji| |
| Abstract | Human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro. TK6 cells have wild-type TP53 alleles, while WTK-1 cells have one allele of mutated TP53. Both cells were treated with 5-fluorouracil (5-FU), and gene mutation assay and micronucleus assay were performed to clarify the differential response related to the TP53 gene status. The effects of 5-FU on gene expression were assessed by microarray and quantitative RT-PCR analyses. In WTK-1 cells, 5-FU increased the frequency of cells with micronucleus and mutation. In TK6 cells, frequency of cells with micronucleus was increased but the mutation frequency was not. The cytotoxicity induced by 5-FU was more prominent in TK6 cells than in WTK-1 cells. Analysis of gene expression showed that the genes involved in the TP53 pathway were up-regulated in TK6 cells but not in WTK-1 cells. The differential responses to 5-FU between these cell lines appeared to be due to the difference in the TP53 gene status, thus providing a molecular basis for the bioassays using these cell lines in the toxicology field. Our results indicate that the clinical efficacy of 5-FU chemotherapy may depend on the TP53 genotype. |
| Keywords | 5-fluorouracil TP53 Tk mutation assays microarray analysis |
| Amo Type | Original Article |
| Published Date | 2012-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 129 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525470 |
| Web of Science KeyUT | 000303175300005 |
| Title Alternative | A CACNB4 mutation showing altered Ca(v)2.1 function in a patient with Dravet syndrome |
|---|---|
| FullText URL | 121_149.pdf |
| Author | Ohmori, Iori| Ouchida, Mamoru| Mimaki, Nobuyoshi| Nishiki, Teiichi| Tomizawa, Kazuhito| Matsui, Hideki| |
| Keywords | てんかん Dravet 症候群 CACNB4遺伝子 SCN1A 遺伝子 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2009-12-01 |
| Volume | volume121 |
| Issue | issue3 |
| Start Page | 149 |
| End Page | 156 |
| ISSN | 0030-1558 |
| language | 日本語 |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.121.149 |
| NAID | 120002308814 |
| Author | Suehisa, Hiroshi| Toyooka, Shinichi| Hotta, Katsuyuki| Uchida, Akiko| Soh, Junichi| Fujiwara, Yoshiro| Matsuo, Keitaro| Ouchida, Mamoru| Takata, Minoru| Kiura, Katsuyuki| Date, Hiroshi| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/49042 |
|---|---|
| FullText URL | 66_6_461.pdf |
| Author | Koike, Kazuko| Takaki, Akinobu| Kato, Nobuyuki| Ouchida, Mamoru| Kanzaki, Hirotaka| Yasunaka, Tetsuya| Shiraha, Hidenori| Miyake, Yasuhiro| Yamamoto, Kazuhide| |
| Abstract | Hepatitis C virus (HCV) infection induces several changes in hepatocytes, such as oxidative stress, steatosis, and hepatocarcinogenesis. Although considerable progress has been made during recent years, the mechanisms underlying these functions remain unclear. We employed proteomic techniques in HCV replicon-harboring cells to determine the effects of HCV replication on host-cell protein expression. We examined two-dimensional electrophoresis (2-DE) and mass spectrometry to compare and identify differentially expressed proteins between HCV subgenomic replicon-harboring cells and their “cured” cells. One of the identified proteins was confirmed using enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Full-length HCV genome RNA replicating and cured cells were also assessed using ELISA. Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. The alteration in RBP expression was also confirmed by ELISA and Western blot analysis. We conclude that protein expression profiling demonstrated that HCV replicon eradication affected retinol-related protein expression. |
| Keywords | hepatitis C virus retinol-binding protein |
| Amo Type | Original Article |
| Published Date | 2012-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 461 |
| End Page | 468 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254580 |
| Web of Science KeyUT | 000312966100005 |
| Author | Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Yamamoto, Hiromasa| Matsubara, Nagahide| Ouchida, Mamoru| Katayama, Hiroshi| Shimizu, Kenji| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54826 |
| FullText URL | EpilepsyRes105_1_220.pdf |
|---|---|
| Author | Ohmori, Iori| Hayashi, Keiichiro| Wang, Haijiao| Ouchida, Mamoru| Fujita, Naohiro| Inoue, Takushi| Michiue, Hiroyuki| Nishiki, Teiichi| Matsui, Hideki| |
| Published Date | 2013-07 |
| Publication Title | Epilepsy Research |
| Volume | volume105 |
| Issue | issue1-2 |
| Publisher | Elsevier Science |
| Start Page | 220 |
| End Page | 224 |
| ISSN | 09201211 |
| NCID | AA10726642 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 23375560 |
| DOI | 10.1016/j.eplepsyres.2013.01.003 |
| Web of Science KeyUT | 000320737500027 |
| Related Url | isVersionOf https://doi.org/10.1016/j.eplepsyres.2013.01.003 |
| Author | Maruo, Tomoko| Ichikawa, Tomotsugu| Kanzaki, Hirotaka| Inoue, Satoshi| Kurozumi, Kazuhiko| Onishi, Manabu| Yoshida, Koichi| Kambara, Hirokazu| Ouchida, Mamoru| Shimizu, Kenji| Tamaru, Seiji| Chiocca, E. Antonio| Date, Isao| |
|---|---|
| Published Date | 2013-06 |
| Publication Title | Neuropathology |
| Volume | volume33 |
| Issue | issue3 |
| Content Type | Journal Article |
| FullText URL | Epilepsia_49_3_521.pdf |
|---|---|
| Author | Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Inoue, Takushi| Shimizu, Kenji| Matsui, Hideki| Ohtsuka, Yoko| Maegaki, Yoshihiro| |
| Keywords | Rasmussen encephalitis SCN1A genetic-environmental interaction |
| Published Date | 2007-11-21 |
| Publication Title | Epilepsia |
| Volume | volume49 |
| Issue | issue3 |
| Publisher | Blackwell |
| Start Page | 521 |
| End Page | 526 |
| ISSN | 0013-9580 |
| NCID | AA00180597 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 18031552 |
| DOI | 10.1111/j.1528-1167.2007.01411.x |
| Web of Science KeyUT | 000253477800020 |
| Related Url | isVersionOf https://doi.org/10.1111/j.1528-1167.2007.01411.x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohmori, Iori| Kobayashi, Kiyoka| Ouchida, Mamoru| |
| Keywords | Scn1a Cacna1a GEFS+ Dravet syndrome Absence seizure Hyperthermia-sensitive seizure Skeletal abnormality GABAergic interneuron Parvalbumin-positive cell |
| Published Date | 2020-12 |
| Publication Title | Neurochemistry International |
| Volume | volume141 |
| Publisher | Elsevier |
| Start Page | 104859 |
| ISSN | 0197-0186 |
| NCID | AA0032399X |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 33045260 |
| DOI | 10.1016/j.neuint.2020.104859 |
| Web of Science KeyUT | 000594993600007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.neuint.2020.104859 |
| Author | Ito, Tatsuo| Ouchida, Mamoru| Morimoto, Yuki| Yoshida, Aki| Jitsumori, Yoshimi| Ozaki, Toshifumi| Sonobe, Hiroshi| Inoue, Hajime| Shimizu, Kenji| |
|---|---|
| Published Date | 2005-06-28 |
| Publication Title | Cancer Letters |
| Volume | volume224 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hayashi, Keiichiro| Ueshima, Satoshi| Ouchida, Mamoru| Mashimo, Tomoji| Nishiki, Teiichi| Sendo, Toshiaki| Serikawa, Tadao| Matsui, Hideki| Ohmori, Iori| |
|---|---|
| Published Date | 2011-05 |
| Publication Title | Epilepsia |
| Volume | volume52 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Yoneda, Yasushi| Ito, Sachio| Kunisada, Toshiyuki| Morimoto, Yuki| Kanzaki, Hirotaka| Yoshida, Aki| Shimizu, Kenji| Ozaki, Toshifumi| Ouchida, Mamoru| |
|---|---|
| Published Date | 2013-10-09 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yano, Masaaki| Ouchida, Mamoru| Shigematsu, Hisayuki| Tanaka, Noriyoshi| Ichimura, Koichi| Kobayashi, Kazuyasu| Inaki, Yasuhiko| Toyooka, Shinichi| Tsukuda, Kazunori| Shimizu, Nobuyoshi| Shimizu, Kenji| |
| Keywords | alternative splicing HELLS loss of heterozygosity lung cancer SMARCA6 |
| Note | Digital Object Identifer:10.1002/ijc.20407<br> Published with permission from the copyright holder. This is the author's copy, as published in the Journal of International Journal of Cancer, October 2004, Volume 112, Issue 1, Pages 8-13.<br> Publisher URL:<a href="http://dx.doi.org/10.1002/ijc.20407" >http://dx.doi.org/10.1002/ijc.20407</a><br> <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=Okayamauniv&SrcApp =Okayamauniv&DestLinkType=FullRecord&KeyUT=000223939100002&DestApp=WOS" >Direct access to Thomson Web of Science record</a><br> Copyright © 2004 Wiley-Liss, Inc. All rights reserved.| |
| Published Date | 2004-10-20 |
| Publication Title | International Journal of Cancer |
| Volume | volume112 |
| Issue | issue1 |
| Publisher | Wiley-Liss, Inc. |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0020-7136 |
| NCID | AA00680002 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Wiley-Liss, Inc. |
| File Version | author |
| PubMed ID | 15305370 |
| DOI | 10.1002/ijc.20407 |
| Web of Science KeyUT | 000223939100002 |
| Author | Ishii, Tatsuhiro| Murakami, Jun| Notohara, Kenji| Sasamoto, Hiromi| Kambara, Takeshi| Shirakawa, Yasuhiro| Naomoto, Yoshio| Ouchida, Mamoru| Shimizu, Kenji| Jeremy, R. Jass| Matsubara, Nagahide| Tanaka, Noriaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
