FullText URL K000901.pdf
Author Ozaki, Toshifumi|
Published Date 1991-03-28
Content Type Thesis or Dissertation
Grant Number 甲第901号
Granted Date 1991-03-28
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language 日本語
FullText URL OTSR105_1_107.pdf Fig.pdf
Author Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Keywords Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting
Published Date 2019-02-28
Publication Title Orthopaedics & Traumatology: Surgery & Research
Volume volume105
Issue issue1
Publisher Elsevier
Start Page 107
End Page 111
ISSN 18770568
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30442555
DOI 10.1016/j.otsr.2018.10.001
Web of Science KeyUT 000456541300018
Related Url isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001
JaLCDOI 10.18926/AMO/30776
FullText URL fulltext.pdf
Author Makihata, Eiichi| Kuroda, Masahiro| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime| Joja, Ikuo| Asaumi, Junichi| Kawasaki, Shoji| Hiraki, Yoshio|
Abstract <p>We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &#60; 0.05) in patients whose Time &#8805; 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p>
Keywords soft tissue tumor hyperthermia radiotherapy chemotherapy
Amo Type Article
Published Date 1997-04
Publication Title Acta Medica Okayama
Volume volume51
Issue issue2
Publisher Okayama University Medical School
Start Page 93
End Page 99
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9142346
Web of Science KeyUT A1997WX19600006
FullText URL IntOrthop_43_5_1239.pdf Tables.pdf Fig.pdf
Author Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Tanaka, Takaaki| Kodama, Yuya| Ozaki, Toshifumi|
Keywords Arthroscopic scoring Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair
Published Date 2018-08-01
Publication Title International Orthopaedics
Volume volume43
Issue issue5
Publisher Springer
Start Page 1239
End Page 1245
ISSN 03412695
NCID AA0068148X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30069591
DOI 10.1007/s00264-018-4071-z
Web of Science KeyUT 000466730800024
Related Url isVersionOf https://doi.org/10.1007/s00264-018-4071-z
FullText URL fulltext.pdf
Author Yamane, Kentaro| Misawa, Haruo| Takigawa, Tomoyuki| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro|
Keywords hepatocyte growth factor spinal cord injury neural regeneration
Published Date 2019-12-02
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue23
Publisher MDPI
Start Page 6078
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31810304
DOI 10.3390/ijms20236078
Web of Science KeyUT 000504428300260
Related Url isVersionOf https://doi.org/10.3390/ijms20236078
JaLCDOI 10.18926/AMO/53910
FullText URL 69_6_355.pdf
Author Okada, Yukimasa| Furumatsu, Takayuki| Miyazawa, Shinichi| Tanaka, Takaaki| Fujii, Masataka| Ozaki, Toshifumi| Abe, Nobuhiro|
Abstract Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8±3.8) and enoxaparin groups (9.4±4.9) than in the control group (15.6±9.8) (p<0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%;fondaparinux, 49.5%;enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used.
Keywords venous thromboembolism contrast-enhanced computed tomography total knee arthroplasty fondaparinux enoxaparin
Amo Type Original Article
Published Date 2015-12
Publication Title Acta Medica Okayama
Volume volume69
Issue issue6
Publisher Okayama University Medical School
Start Page 355
End Page 359
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26690246
Web of Science KeyUT 000368434500005
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Sugiu, Kazuhisa| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
Note This fulltext will be available in Nov 2020 |
Published Date 2019-08-20
Publication Title Journal of Orthopaedic Science
Volume volume24
Issue issue6
Publisher Elsevier
Start Page 1058
End Page 1063
ISSN 09492658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
File Version author
PubMed ID 31444009
DOI 10.1016/j.jos.2019.08.001
Web of Science KeyUT 000496202800019
Related Url isVersionOf https://doi.org/10.1016/j.jos.2019.08.001
Author Kunisada, Toshiyuki| Ozaki, Toshifumi|
Published Date 2008-05-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue1
Content Type Journal Article
FullText URL CTR_2019_1631298.pdf Fig.pdf
Author Hino, Tomohito| Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Kodama, Yuya| Kamatsuki, Yusuke| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Ozaki, Toshifumi|
Keywords Medial meniscus posterior insertion histological analysis knee osteoarthritis medial meniscus posterior root tear transtibial pullout repair
Published Date 2019-07-09
Publication Title Connective Tissue Research
Volume volume61
Issue issue6
Publisher Taylor and Francis
Start Page 546
End Page 553
ISSN 0300-8207
NCID AA00615033
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31181971
DOI 10.1080/03008207.2019.1631298
Web of Science KeyUT 000478374800001
Related Url isVersionOf https://doi.org/10.1080/03008207.2019.1631298
JaLCDOI 10.18926/AMO/57717
FullText URL 73_6_523.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yoshiki| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
Abstract The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred > 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thus contribute to anatomical MM posterior root repair and ACL reconstruction.
Keywords bilateral anterior cruciate ligament tear medial meniscus posterior root tear pullout repair case report
Amo Type Case Report
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 523
End Page 528
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871335
Web of Science KeyUT 000503431400008
Author Okazaki, Yuki| Furumatsu, Takayuki| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
Keywords Magnetic resonance imaging Medial meniscus Meniscus extrusion Posterior root tear Three-dimensional assessment
Note This fulltext is available in Feb. 2021.|
Published Date 2020-01-01
Publication Title The Knee
Volume volume27
Issue issue1
Publisher Elsevier
Start Page 132
End Page 139
ISSN 09680160
NCID AA10996272
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31882388
DOI 10.1016/j.knee.2019.09.005
Web of Science KeyUT 000519666300017
Related Url isVersionOf https://doi.org/10.1016/j.knee.2019.09.005
Author 尾﨑 敏文|
Published Date 2006-01-04
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/30739
FullText URL fulltext.pdf
Author Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu|
Abstract The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis.
Keywords neurotrophin Trk distraction osteogenesis mechanical stress
Amo Type Article
Published Date 2006-10
Publication Title Acta Medica Okayama
Volume volume60
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17072373
Web of Science KeyUT 000241509000003
JaLCDOI 10.18926/AMO/30749
FullText URL fulltext.pdf
Author Komiyama, Takamitsu| Nishida, Keiichiro| Yorimitsu, Masanori| Doi, Hideyuki| Miyazawa, Shinichi| Kitamura, Ai| Yoshida, Aki| Nasu, Yoshihisa| Abe, Nobuhiro| Ozaki, Toshifumi|
Abstract Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p&#60;0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
Keywords spontaneous hypertensive rats insulin like growth factor-1 vascular endothelial growth factor ossification disturbance osteonecrosis
Amo Type Article
Published Date 2006-06
Publication Title Acta Medica Okayama
Volume volume60
Issue issue3
Publisher Okayama University Medical School
Start Page 141
End Page 148
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16838042
Web of Science KeyUT 000238503600001
FullText URL fulltext.pdf
Author Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Misawa, Haruo| Takigawa, Tomoyuki| Yamane, Kentaro| Tsuji, Hironori| Takei, Yoshitaka| Ozaki, Toshifumi|
Keywords Peripheral neuropathic pain Mirogabalin Pregabalin Adverse event
Published Date 2020-05-26
Publication Title Journal of Orthopaedic Surgery and Research
Volume volume15
Issue issue1
Publisher Springer
Start Page 191
ISSN 1749-799X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 32456647
DOI 10.1186/s13018-020-01709-3
Web of Science KeyUT 000538017400002
Related Url isVersionOf https://doi.org/10.1186/s13018-020-01709-3
JaLCDOI 10.18926/AMO/30784
FullText URL fulltext.pdf
Author Kunisada, Toshiyuki| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Taguchi, Kohji| Inoue, Hajime|
Abstract <p>In this study, we reviewed the clinical features of 11 patients with malignant schwannoma who were treated in our institute. Five patients had coexistent von Recklinghausen's disease and one of them showed multifocal occurrence. Patients with the centrally located tumors had a poorer prognosis than those with the others. The overall 3-year survival rate was 36%; 40% in patients with von Recklinghausen's disease and 33% in the others. At the time of the last follow-up, 9 patients had died of the tumor, one continued to be tumor free, and one was alive with tumor. Postoperative local recurrence developed in 5 patients (45%); 4 out of 6 patients (67%) who underwent a marginal excision and one out of 3 (33%) who underwent primary amputation. There was no local recurrence in patients after a wide excision with at least 3cm of normal tissue removed surrounding the tumor in all directions. Nine patients (82%) developed pulmonary metastasis. The effect of adjuvant chemotherapy was not clear in this study. The high risk of pulmonary metastasis in this disease indicates the necessity of more effective adjuvant chemotherapy.</p>
Keywords malignant schwannoma clinical analysis von Recklinghausen's disease
Amo Type Article
Published Date 1997-04
Publication Title Acta Medica Okayama
Volume volume51
Issue issue2
Publisher Okayama University Medical School
Start Page 87
End Page 92
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9142345
Web of Science KeyUT A1997WX19600005
JaLCDOI 10.18926/AMO/30956
FullText URL fulltext.pdf
Author Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi|
Abstract <p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p>
Keywords IL-4 MMP cathepsin B mechanical stress aggrecanase
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 126
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464888
Web of Science KeyUT 000255297600008
JaLCDOI 10.18926/AMO/31335
FullText URL fulltext.pdf
Author Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime|
Abstract <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p>
Keywords osteosarcoma bone transport reconstruction
Amo Type Article
Published Date 1998-02
Publication Title Acta Medica Okayama
Volume volume52
Issue issue1
Publisher Okayama University Medical School
Start Page 67
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9548997
Web of Science KeyUT 000072264100010
JaLCDOI 10.18926/AMO/31340
FullText URL fulltext.pdf
Author Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime|
Abstract <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p>
Keywords osteosarcoma bone transport reconstruction
Amo Type Article
Published Date 1998-02
Publication Title Acta Medica Okayama
Volume volume52
Issue issue1
Publisher Okayama University Medical School
Start Page 67
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9548997
Web of Science KeyUT 000072264100010
JaLCDOI 10.18926/AMO/49259
FullText URL 67_1_65.pdf
Author Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi|
Abstract Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects.
Keywords bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 74
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439511
Web of Science KeyUT 000316829900009