Otsuka, Fumio - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Changes in Prescribing Patterns of Antiviral Drugs before and after Public Coverage Termination among Hospitalized COVID-19 Patients in Regional Hospitals in Japan: A Retrospective, Multicenter Study

JaLCDOI	10.18926/AMO/70073
FullText URL	80_1_055.pdf
Author	Akazawa, Hidemasa\| Hagiya, Hideharu\| Fukushima, Shinnosuke\| Yamamoto, Shohei\| Nakano, Yasuhiro\| Otsuka, Fumio\|
Abstract	In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations.
Keywords	coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2026-02
Volume	volume80
Issue	issue1
Publisher	Okayama University Medical School
Start Page	55
End Page	62
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2026 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	41748150
Web of Science KeyUT	001712994500007

Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard ACD-A

FullText URL	fulltext.pdf
Author	Fujii, Keiko\| Kitamura, Wataru\| Washio, Kana\| Ikeuchi, Kazuhiro\| Shimono, Joji\| Murakami, Hiroyuki\| Otsuka, Fumio\| Maeda, Yoshinobu\| Fujii, Nobuharu\|
Keywords	acid citrate dextrose solution autologous continuous mononuclear cell collection highly concentrated sodium pediatric peripheral blood stem cells
Published Date	2026-02-02
Publication Title	Transfusion
Publisher	Wiley
ISSN	0041-1132
NCID	AA00868753
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41630350
DOI	10.1111/trf.70102
Related Url	isVersionOf https://doi.org/10.1111/trf.70102

Whole-genome sequencing and in vitro characterization of a disseminated ST398 Staphylococcus aureus infection: A case report

Author	Sazumi, Yosuke\| Fukushima, Shinnosuke\| Hagiya, Hideharu\| Kato, Atsushi\| Suyama, Atsuhito\| Oguni, Kohei\| Gotoh, Kazuyoshi\| Kutsuno, Shoko\| Hisatsune, Junzo\| Sugai, Motoyuki\| Tsuji, Shuma\| Iio, Koji\| Otsuka, Fumio\|
Keywords	Staphylococcus aureus Sequence type 398 Disseminated infection Immune evasion cluster gene
Note	© 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Oct. 2026.\|
Published Date	2025-12
Publication Title	Journal of Infection and Chemotherapy
Volume	volume31
Issue	issue12
Publisher	Elsevier BV
Start Page	102845
ISSN	1341-321X
NCID	AA11057978
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version	author
PubMed ID	41161474
DOI	10.1016/j.jiac.2025.102845
Web of Science KeyUT	001611880300001
Related Url	isVersionOf https://doi.org/10.1016/j.jiac.2025.102845

Cerebellar abscess caused by Cladophialophora bantiana involving an elderly Japanese woman

Author	Nakamoto, Kenta\| Hagiya, Hideharu\| Fukushima, Shinnosuke\| Oguni, Kohei\| Yokoyama, Yukika\| Iio, Koji\| Hirano, Shuichiro\| Yaguchi, Takashi\| Ban, Sayaka\| Watanabe, Akira\| Okunobu, Hiroki\| Suyama, Atsuhito\| Kawaguchi, Marina\| Sazumi, Yousuke\| Otsuka, Fumio\|
Keywords	Brain abscess Cladophialophora bantiana Black fungus Phaeohyphomycosis Posaconazole
Note	© 2025 SFMM. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Mar. 2026.\|
Published Date	2025-06
Publication Title	Journal of Medical Mycology
Volume	volume35
Issue	issue2
Publisher	Elsevier BV
Start Page	101548
ISSN	1156-5233
NCID	AA11001383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 SFMM.
File Version	author
PubMed ID	40168940
DOI	10.1016/j.mycmed.2025.101548
Web of Science KeyUT	001460918900001
Related Url	isVersionOf https://doi.org/10.1016/j.mycmed.2025.101548

Focal Nodular Hyperplasia of the Liver Mimicking Gastric Submucosal Tumor

FullText URL	fulltext.pdf
Author	Masuda, Yohei\| Otsuka, Yuki\| Soejima, Yoshiaki\| Otsuka, Fumio\|
Keywords	extragastric compression focal liver lesions focal nodular hyperplasia gastric submucosal tumor spoke-wheel pattern
Published Date	2025-12
Publication Title	Clinical Case Reports
Volume	volume13
Issue	issue12
Publisher	Wiley
Start Page	e71666
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	41368062
DOI	10.1002/ccr3.71666
Web of Science KeyUT	001633808000001
Related Url	isVersionOf https://doi.org/10.1002/ccr3.71666

Molecular epidemiological investigation of the carbapenemase-producing Enterobacterales isolates in Okayama prefecture, Japan

FullText URL	fulltext.pdf
Author	Tsuji, Shuma\| Fukushima, Shinnosuke\| Gotoh, Kazuyoshi\| Iio, Koji\| Sato, Mayu\| Inoue, Yasurou\| Sakita, Sayaka\| Fudeyasu, Tomoko\| Otsuka, Fumio\| Hagiya, Hideharu\|
Keywords	Antimicrobial resistance Carbapenemase-producing Enterobacterales New Delhi metallo-β-lactamase Klebsiella pneumoniae carbapenemase Genomic surveillance
Published Date	2026-03
Publication Title	Diagnostic Microbiology and Infectious Disease
Volume	volume114
Issue	issue3
Publisher	Elsevier BV
Start Page	117209
ISSN	0732-8893
NCID	AA10623322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	41343892
DOI	10.1016/j.diagmicrobio.2025.117209
Web of Science KeyUT	001635147000001
Related Url	isVersionOf https://doi.org/10.1016/j.diagmicrobio.2025.117209

Interaction Between Thyroid Hormones and Bone Morphogenetic Proteins in the Regulation of Steroidogenesis by Granulosa Cells

FullText URL	fulltext.pdf
Author	Motohashi, Kanon\| Soejima, Yoshiaki\| Yamamoto, Koichiro\| Iwata, Nahoko\| Suyama, Atsuhito\| Nakano, Yasuhiro\| Otsuka, Fumio\|
Keywords	bone morphogenetic protein (BMP) thyroid hormone steroidogenesis ovary
Published Date	2025-09-18
Publication Title	International Journal of Molecular Sciences
Volume	volume26
Issue	issue18
Publisher	MDPI AG
Start Page	9127
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	41009688
DOI	10.3390/ijms26189127
Web of Science KeyUT	001580156800001
Related Url	isVersionOf https://doi.org/10.3390/ijms26189127

Clinical Evaluation of Oxidative Stress Markers in Patients with Long COVID During the Omicron Phase in Japan

FullText URL	fulltext.pdf
Author	Mese, Osamu\| Otsuka, Yuki\| Sakurada, Yasue\| Tokumasu, Kazuki\| Soejima, Yoshiaki\| Morita, Satoru\| Nakano, Yasuhiro\| Honda, Hiroyuki\| Eguchi, Akiko\| Fukuda, Sanae\| Nojima, Junzo\| Otsuka, Fumio\|
Keywords	biological antioxidant potential (BAP) Coronavirus disease 2019 (COVID-19) diacron-reactive oxygen metabolites (d-ROM) Long COVID oxidative stress index (OSI)
Published Date	2025-08-30
Publication Title	Antioxidants
Volume	volume14
Issue	issue9
Publisher	MDPI AG
Start Page	1068
ISSN	2076-3921
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	41008975
DOI	10.3390/antiox14091068
Web of Science KeyUT	001579416500001
Related Url	isVersionOf https://doi.org/10.3390/antiox14091068

Factors affecting the development of hypokalemia during apheresis in healthy donors

FullText URL	fulltext.pdf
Author	Kitamura, Wataru\| Fujii, Keiko\| Kobayashi, Hiroki\| Abe, Masaya\| Fukumi, Takuya\| Ikeuchi, Kazuhiro\| Otsuka, Fumio\| Maeda, Yoshinobu\| Fujii, Nobuharu\|
Keywords	Allogeneic Peripheral blood stem cells Hypokalemia Acid citrate dextrose solution A Healthy donors
Published Date	2025-08
Publication Title	Transfusion and Apheresis Science
Volume	volume64
Issue	issue4
Publisher	Elsevier BV
Start Page	104195
ISSN	1473-0502
NCID	AA11555942
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	40561934
DOI	10.1016/j.transci.2025.104195
Web of Science KeyUT	10.1016/j.transci.2025.104195
Related Url	isVersionOf https://doi.org/10.1016/j.transci.2025.104195

Symptomatic Trends and Time to Recovery for Long COVID Patients Infected During the Omicron Phase

FullText URL	fulltext.pdf
Author	Akiyama, Hiroshi\| Sakurada, Yasue\| Honda, Hiroyuki\| Matsuda, Yui\| Otsuka, Yuki\| Tokumasu, Kazuki\| Nakano, Yasuhiro\| Takase, Ryosuke\| Omura, Daisuke\| Ueda, Keigo\| Otsuka, Fumio\|
Keywords	fatigue headache insomnia long COVID Omicron variants recovery
Published Date	2025-07-11
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue14
Publisher	MDPI AG
Start Page	4918
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40725611
DOI	10.3390/jcm14144918
Web of Science KeyUT	001535803000001
Related Url	isVersionOf https://doi.org/10.3390/jcm14144918

Video review by utilizing asynchronous video communication platform

FullText URL	fulltext.pdf
Author	Otsuka, Yuki\| Mitsuda, Eiko\| Yamamoto, Yukichika\| Kato, Atsushi\| Soshi, Mano\| Higuchi, Masaya\| Obika, Mikako\| Otsuka, Fumio\| Hashimoto, Tadayuki\|
Keywords	feedback general medicine video review
Published Date	2025-02-21
Publication Title	Journal of General and Family Medicine
Volume	volume26
Issue	issue4
Publisher	Wiley
Start Page	375
End Page	378
ISSN	2189-7948
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40642125
DOI	10.1002/jgf2.70005
Web of Science KeyUT	001426999000001
Related Url	isVersionOf https://doi.org/10.1002/jgf2.70005

Novel leukocytapheresis method using highly concentrated sodium citrate solution for the manufacturing of tisagenlecleucel

FullText URL	fulltext.pdf
Author	Kitamura, Wataru\| Fujii, Keiko\| Abe, Masaya\| Ikeuchi, Kazuhiro\| Washio, Kana\| Otsuka, Fumio\| Maeda, Yoshinobu\| Fujii, Nobuharu\|
Keywords	Chimeric antigen receptor T cell therapy Anticoagulant Acid citrate dextrose solution A Highly concentrated sodium citrate
Published Date	2025-12
Publication Title	Transfusion and Apheresis Science
Volume	volume64
Issue	issue6
Publisher	Elsevier BV
Start Page	104265
ISSN	1473-0502
NCID	AA11555942
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	41109063
DOI	10.1016/j.transci.2025.104265
Web of Science KeyUT	001601254900001
Related Url	isVersionOf https://doi.org/10.1016/j.transci.2025.104265

Novel method for autologous peripheral blood stem cell harvest using highly concentrated sodium citrate solution replacing acid citrate dextrose solution A

FullText URL	fulltext.pdf
Author	Kitamura, Wataru\| Fujii, Keiko\| Abe, Masaya\| Ikeuchi, Kazuhiro\| Shimono, Joji\| Washio, Kana\| Otsuka, Fumio\| Maeda, Yoshinobu\| Fujii, Nobuharu\|
Keywords	acid citrate dextrose solution A anticoagulant autologous highly concentrated sodium citrate peripheral blood stem cell
Published Date	2025-07-25
Publication Title	Transfusion
Volume	volume65
Issue	issue9
Publisher	Wiley
Start Page	1662
End Page	1672
ISSN	0041-1132
NCID	AA00868753
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40708443
DOI	10.1111/trf.18360
Web of Science KeyUT	001535020500001
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A Case of Netherton Syndrome/SPINK5-Syndromic Epidermal Differentiation Disorder Evaluated by Serial Tape-Stripping: Persistent Elevation of Serine Protease Activities Despite Clinical Improvement

Author	Morizane, Shin\| Morita, Anri\| Sunagawa, Ko\| Nomura, Hayato\| Hasui, Ken‐Ichi\| Honda, Hiroyuki\| Otsuka, Fumio\| Ouchida, Mamoru\|
Keywords	kallikrein-related peptidase lympho- epithelial Kazal-type-related inhibitor Netherton syndrome/SPINK5-syndromic epidermaldifferentiation disorder RNA sequencing serine protease activity tape-stripping
Note	This is the peer reviewed version of the following article: S. Morizane, A. Morita, K. Sunagawa, et al., “ A Case of Netherton Syndrome/SPINK5-Syndromic Epidermal Differentiation Disorder Evaluated by Serial Tape-Stripping: Persistent Elevation of Serine Protease Activities Despite Clinical Improvement,” The Journal of Dermatology (2025): 1–3, https://doi.org/10.1111/1346-8138.70007., which has been published in final form at https://doi.org/10.1111/1346-8138.70007. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in Oct. 2026.\|
Published Date	2025-10-06
Publication Title	The Journal of Dermatology
Publisher	Wiley
ISSN	0385-2407
NCID	AA00696658
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Japanese Dermatological Association.
File Version	author
PubMed ID	41047924
DOI	10.1111/1346-8138.70007
Web of Science KeyUT	001588308300001
Related Url	isVersionOf https://doi.org/10.1111/1346-8138.70007

Computed tomography findings of idiopathic multicentric Castleman disease subtypes

FullText URL	fulltext.pdf
Author	Iguchi, Toshihiro\| Nishikori, Asami\| Sato, Yasuharu\| Nishimura, Midori Filiz\| Iwaki, Noriko\| Kojima, Katsuhide\| Asahara, Takashi\| Otsuka, Fumio\| Maeda, Yoshinobu\| Hiraki, Takao\|
Keywords	idiopathic multicentric Castleman disease TAFRO syndrome computed tomography
Published Date	2024-12-25
Publication Title	Journal of Clinical and Experimental Hematopathology
Volume	volume64
Issue	issue4
Publisher	Japanese Society for Lymphoreticular Tissue Research
Start Page	292
End Page	296
ISSN	1346-4280
NCID	AA11556796
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by The Japanese Society for Lymphoreticular Tissue Research
File Version	publisher
PubMed ID	39721711
DOI	10.3960/jslrt.24053
CRID	1390584099501917312
Web of Science KeyUT	001417179400004
Related Url	isVersionOf https://doi.org/001417179400004

Is subclinical hypothyroidism associated with cardiovascular disease in the elderly?

FullText URL	fulltext.pdf
Author	Yamamoto, Koichiro\| Nakano, Yasuhiro\| Soejima, Yoshiaki\| Suyama, Atsuhito\| Oguni, Kohei\| Hasegawa, Kou\| Otsuka, Fumio\|
Keywords	cardiovascular disease elderly patients subclinical hypothyroidism thyroid disease
Published Date	2025-03-20
Publication Title	Endocrine Connections
Volume	volume14
Issue	issue5
Publisher	Bioscientifica
Start Page	e240601
ISSN	2049-3614
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 the author(s)
File Version	publisher
PubMed ID	40110943
DOI	10.1530/ec-24-0601
Web of Science KeyUT	001551195800020
Related Url	isVersionOf https://doi.org/10.1530/ec-24-0601

Clinical Characteristics of Vitamin D Deficiency Detected in Long COVID Patients During the Omicron Phase

FullText URL	fulltext.pdf
Author	Matsuda, Yui\| Sakurada, Yasue\| Nakano, Yasuhiro\| Otsuka, Yuki\| Tokumasu, Kazuki\| Honda, Hiroyuki\| Soejima, Yoshiaki\| Yokota, Yuya\| Takase, Ryosuke\| Omura, Daisuke\| Otsuka, Fumio\|
Keywords	COVID-19 25-hydroxyvitamin D long COVID palpitation vitamin D deficiency
Published Date	2025-05-16
Publication Title	Nutrients
Volume	volume17
Issue	issue10
Publisher	MDPI AG
Start Page	1692
ISSN	2072-6643
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40431432
DOI	10.3390/nu17101692
Web of Science KeyUT	001495601700001
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Novel method of leukocytapheresis using a highly concentrated sodium citrate solution alternative to acid citrate dextrose solution A

FullText URL	fulltext.pdf
Author	Abe, Masaya\| Fujii, Keiko\| Mitsuhashi, Toshiharu\| Kitamura, Wataru\| Ikeuchi, Kazuhiro\| Fukumi, Takuya\| Washio, Kana\| Otsuka, Fumio\| Maeda, Yoshinobu\| Fujii, Nobuharu\|
Keywords	anticoagulant apheresis high sodium citrate concentration Spectra Optia
Published Date	2025-05-19
Publication Title	Transfusion
Publisher	Wiley
ISSN	0041-1132
NCID	AA00868753
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40387021
DOI	10.1111/trf.18280
Web of Science KeyUT	001490160900001
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Impact of Lifestyle Changes on Body Weight Gain During Nationwide Lockdown Due to COVID-19 Pandemic

FullText URL	fulltext.pdf
Author	Nishida, Chisa\| Honda, Hiroyuki\| Otsuka, Yuki\| Hagiya, Hideharu\| Nakano, Yasuhiro\| Oguni, Kohei\| Tokumasu, Kazuki\| Sakurada, Yasue\| Obika, Mikako\| Otsuka, Fumio\|
Keywords	COVID-19 pandemic lockdown weight gain medical check-ups lifestyle
Published Date	2025-03-25
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue7
Publisher	MDPI
Start Page	2242
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40217694
DOI	10.3390/jcm14072242
Web of Science KeyUT	001463577200001
Related Url	isVersionOf https://doi.org/10.3390/jcm14072242

Involvement of a Novel Variant of FGFR1 Detected in an Adult Patient with Kallmann Syndrome in Regulation of Gonadal Steroidogenesis

FullText URL	fulltext.pdf
Author	Soejima, Yoshiaki\| Otsuka, Yuki\| Kawaguchi, Marina\| Oguni, Kohei\| Yamamoto, Koichiro\| Nakano, Yasuhiro\| Yasuda, Miho\| Tokumasu, Kazuki\| Ueda, Keigo\| Hasegawa, Kosei\| Iwata, Nahoko\| Otsuka, Fumio\|
Keywords	fibroblast growth factor receptor 1 (FGFR1) gynecomastia Kallmann syndrome (KS) osteoporosis and steroidogenesis
Published Date	2025-03-18
Publication Title	International Journal of Molecular Sciences
Volume	volume26
Issue	issue6
Publisher	MDPI
Start Page	2713
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40141355
DOI	10.3390/ijms26062713
Web of Science KeyUT	001452479200001
Related Url	isVersionOf https://doi.org/10.3390/ijms26062713