| JaLCDOI | 10.18926/AMO/60806 |
|---|---|
| FullText URL | 74_5_443.pdf |
| Author | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
| Abstract | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
| Keywords | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
| Amo Type | Case Report |
| Note | Fig. 1B is replaced on Dec. 23, 2020.| |
| Published Date | 2020-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 443 |
| End Page | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106702 |
| Title Alternative | Development of artificial intelligence (AI) in medical field |
|---|---|
| FullText URL | 132_91.pdf |
| Author | Nasu, Yasutomo| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2020-08-03 |
| Volume | volume132 |
| Issue | issue2 |
| Start Page | 91 |
| End Page | 91 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.132.91 |
| language | 日本語 |
| Copyright Holders | Copyright (c) 2020 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.132.91 |
| NAID | 130007894958 |
| JaLCDOI | 10.18926/AMO/47013 |
|---|---|
| FullText URL | 65_5_315.pdf |
| Author | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
| Abstract | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
| Keywords | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
| Amo Type | Original Article |
| Published Date | 2011-10 |
| Publication Title | Acta Medica Okayama |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400005 |
| Author | Tanaka, Takashi| Huang, Yong| Marukawa, Yohei| Tsuboi, Yuka| Masaoka, Yoshihisa| Kojima, Katsuhide| Iguchi, Toshihiro| Hiraki, Takao| Gobara, Hideo| Yanai, Hiroyuki| Nasu, Yasutomo| Kanazawa, Susumu| |
|---|---|
| Keywords | MDCT artificial intelligence kidney neoplasms neural network models |
| Published Date | 2020-01-08 |
| Publication Title | American journal of roentgenology |
| Publisher | American Roentgen Ray Society |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0361-803X |
| NCID | AA00521224 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31913072 |
| DOI | 10.2214/AJR.19.22074 |
| Related Url | isVersionOf https://doi.org/10.2214/AJR.19.22074 |
| JaLCDOI | 10.18926/AMO/54423 |
|---|---|
| FullText URL | 70_3_223.pdf |
| Author | Ebara, Shin| Kobayashi, Yasuyuki| Sasaki, Katsumi| Araki, Motoo| Sugimoto, Morito| Wada, Koichirou| Fujio, Kei| Takamoto, Atsushi| Watanabe, Toyohiko| Yanai, Hiroyuki| Nasu, Yasutomo| |
| Abstract | The present case report describes a case of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy and adjuvant chemotherapy consisting of irinotecan and cisplatin in a 32-year-old man. He received gemcitabine/cisplatin/ paclitaxel (GCP) combination chemotherapy, consisting of gemcitabin (1,000mg/m2) on day 1, 8, cisplatin (70mg/m2) on day 1, and paclitaxel (80mg/m2) on day 1 and 8. After three cycles of chemotherapy, PET-CT showed complete regression of the disease. So the patient underwent total cystourethrectomy, and histological examination showed an almost complete pathological response. External beam radiation therapy was also given to the ileac bone metastasis regions. However, PET-CT taken 17 months after the external beam radiation showed multiple lung metastases. He received GCP chemotherapy again, which resulted in a complete response again after three cycles of chemotherapy. This is the first report on GCP chemotherapy used not only as a salvage chemotherapy but also as a rechallenge regimen for metastatic urachal cancer including a neuroendocrine component. |
| Amo Type | Case Report |
| Published Date | 2016-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 223 |
| End Page | 227 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339213 |
| Web of Science KeyUT | 000379406100011 |
| Author | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Endocrine Journal |
| Volume | volume60 |
| Issue | issue12 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/57953 |
|---|---|
| FullText URL | 74_1_53.pdf |
| Author | Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery. |
| Keywords | renal autotransplantation robotic porcine model transplantation |
| Amo Type | Original Article |
| Published Date | 2020-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099249 |
| Web of Science KeyUT | 000516606200008 |
| NAID | 120006795620 |
| Author | Waki, Takahiro| Katsui, Kuniaki| Mitsuhashi, Toshiharu| Ogata, Takeshi| Katayama, Norihisa| Takemoto, Mitsuhiro| Nasu, Yasutomo| Kumon, Hiromi| Kanazawa, Susumu| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54823 |
| JaLCDOI | 10.18926/AMO/54507 |
|---|---|
| FullText URL | 70_4_295.pdf |
| Author | Araki, Motoo| Wada, Koichiro| Mitsui, Yosuke| Kubota, Risa| Yoshioka, Takashi| Ariyoshi, Yuichi| Kobayashi, Yasuyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hiroshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo| |
| Abstract | Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients. |
| Keywords | end-stage renal disease immunosuppression kidney transplantation |
| Amo Type | Clinical Study Protocols |
| Published Date | 2016-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 295 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549676 |
| Web of Science KeyUT | 000384748600011 |
| JaLCDOI | 10.18926/AMO/55205 |
|---|---|
| FullText URL | 71_3_227.pdf |
| Author | Sasaki, Katsumi| Wada, Koichiro| Araki, Motoo| Kobayashi, Yasuyuki| Sugimoto, Morito| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We elucidate the fate of cases clinically suspected of carcinoma in situ (Cis) of the upper tract with serial ureteroscopy. Of 143 patients who underwent ureteroscopy for suspected upper tract urothelial carcinoma (UTUC) between January 2008 and February 2016, 12 cases with consistently positive urine cytology and poorly detectable upper-tract malignancies by imaging were reviewed. In these 12 patients, 19 ureteroscopy procedures (25 renal units) were performed. Vesical random biopsy was performed before the 1st ureteroscopy to exclude malignancy of the bladder in all 12 cases. Median follow-up was 42 (13-67) months. Positive biopsy results at the 1st ureteroscopy were obtained in 3 (25%) patients and all were diagnosed wth Cis of the upper tract. Two (17%) of 9 patients who were negative or inconclusive at the 1st ureteroscopy were finally diagnosed as UTUC, but plural ureteroscopy procedures were needed for the diagnoses in both. Carcinoma of the bladder appeared in 5 (42%) patients during follow-up, despite the earlier ruling out of vesical malignancy. Four (33%) of those 5 patients never developed upper-tract urothelial carcinoma during follow-up. Caution is required before undertaking radical surgery for cases clinically suspected of Cis of the upper tract. In our experience, only 42% of such patients developed UTUC; another 33% eventually developed carcinoma of the bladder without UTUC. |
| Keywords | carcinoma in situ carcinoma of the bladder upper tract urothelial carcinoma ureteroscopy urine cytology |
| Amo Type | Original Article |
| Published Date | 2017-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 232 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655942 |
| JaLCDOI | 10.18926/AMO/54989 |
|---|---|
| FullText URL | 71_2_187.pdf |
| Author | Takamoto, Atsushi| Araki, Motoo| Wada, Koichiro| Sugimoto, Morito| Kobayashi, Yasuyuki| Sasaki, Katsumi| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We report the case of a 58-year-old Japanese man with bilateral synchronous renal cell carcinoma (RCC). The diameters of the right and left tumors were 56 and 69 mm, respectively. Both tumors were endophytic. Cryoablation with prophylactic embolization was performed for the left tumor, and 1 month later, a right open partial nephrectomy was performed. No recurrence was observed during a 16-month follow-up, and the serum creatinine level has been stable. The prognosis of bilateral synchronous RCC is better than that of dialysis patients. The novel approach of combining cryoablation and partial nephrectomy can achieve good cancer control and renal function in bilateral RCC. |
| Keywords | cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma synchronous multiple primary |
| Amo Type | Case Report |
| Published Date | 2017-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 187 |
| End Page | 190 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420902 |
| Author | Tanimoto, Ryuta| Sakaguchi, Masakiyo| Abarzua, Fernando| Kataoka, Ken| Kurose, Kaoru| Murata, Hitoshi| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-Ho| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | International Journal of Cancer |
| Volume | volume126 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Sakaguchi, Masakiyo| Kataoka, Ken| Abarzua, Fernando| Tanimoto, Ryuta| Watanabe, Masami| Murata, Hitoshi| Than, Swe Swe| Kurose, Kaoru| Kashiwakura, Yuji| Ochiai, Kazuhiko| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-ho| |
|---|---|
| Published Date | 2009-05-22 |
| Publication Title | The Journal of Biological Chemistry |
| Volume | volume284 |
| Issue | issue21 |
| Content Type | Journal Article |
| Author | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-05 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume138 |
| Issue | issue5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54508 |
|---|---|
| FullText URL | 70_4_299.pdf |
| Author | Wada, Koichiro| Uehara, Shinya| Ishii, Ayano| Sadahira, Takuya| Yamamoto, Masumi| Mitsuhata, Ritsuko| Takamoto , Atsushi| Araki, Motoo| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo| |
| Abstract | Urinary tract infections (UTIs) are the most common bacterial infections in women, and many patients experience frequent recurrence. The aim of this report is to introduce an on-going prospective phase II clinical trial performed to evaluate the preventive effectiveness of Lactobacillus vaginal suppositories for prevention of recurrent cystitis. Patients enrolled in this study are administered vaginal suppositories containing the GAI 98322 strain of Lactobacillus crispatus every 2 days or 3 times a week for one year. The primary endpoint is recurrence of cystitis and the secondary endpoints are adverse events. Recruitment began in December 2013 and target sample size is 20 participants. |
| Keywords | probiotics lactobacilli Lactobacillus crispatus urinary tract infection vaginal suppository |
| Amo Type | Clinical Study Protocols |
| Published Date | 2016-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 302 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549677 |
| Web of Science KeyUT | 000384748600012 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Xu, Naijin| Lin, Wenfeng| Sun, Jingkai| Sadahira, Takuya| Xu, Abai| Watanabe, Masami| Guo, Kai| Araki, Motoo| Li, Gonghui| Liu, Chunxiao| Nasu, Yasutomo| Huang, Peng| |
| Keywords | Nitroxoline Bladder cancer EMT immunotherapy preclinical model |
| Published Date | 2020-09-23 |
| Publication Title | Journal of Cancer |
| Volume | volume11 |
| Issue | issue22 |
| Publisher | Ivyspring International Publisher |
| Start Page | 6633 |
| End Page | 6641 |
| ISSN | 1837-9664 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The author(s). |
| File Version | publisher |
| PubMed ID | 33046984 |
| DOI | 10.7150/jca.47025 |
| Web of Science KeyUT | 000575099000017 |
| Related Url | isVersionOf https://doi.org/10.7150/jca.47025 |
| JaLCDOI | 10.18926/AMO/54982 |
|---|---|
| FullText URL | 71_2_135.pdf |
| Author | Mori, Akihiro| Watanabe, Masami| Sadahira, Takuya| Kobayashi, Yasuyuki| Ariyoshi, Yuichi| Ueki, Hideo| Wada, Koichiro| Ochiai, Kazuhiko| Li, Shun-Ai| Nasu, Yasutomo| |
| Abstract | The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells. Western blotting revealed that the expression of CD147 was significantly suppressed by Ad-REIC. Ad-REIC also suppressed the cell growth of LNCaP cells. Since other researchers have demonstrated that phosphorylated mitogen-activated protein kinases (MAPKs) and c-Myc protein positively regulate the expression of CD147, we investigated the correlation between the CD147 level and the activation of MAPK and c-Myc expression. Unexpectedly, no positive correlation was observed between CD147 and its possible regulators, suggesting that another signaling pathway was involved in the downregulation of CD147. This is the first study to show the downregulation of CD147 by Ad-REIC in prostate cancer cells. At least some of the therapeutic effects of Ad-REIC may be due to the downregulation of the cancer-progression factor, CD147. |
| Keywords | prostate cancer REIC/Dkk-3 CD147 cell growth p38 MAP kinase |
| Amo Type | Original Article |
| Published Date | 2017-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420895 |
| Author | Bekku, Kensuke| Saika, Takashi| Kobayashi, Yasuyuki| Kioshimoto, Ryo| Kanbara, Taiki| Nasu, Yasutomo| Kumon, Hiromi| |
|---|---|
| Published Date | 2013-02 |
| Publication Title | International Journal of Clinical Oncology |
| Volume | volume18 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/45274 |
|---|---|
| FullText URL | 65_2_143.pdf |
| Author | Kobayashi, Yasuyuki| Saika, Takashi| Manabe, Daisuke| Nasu, Yasutomo| Kumon, Hiromi| |
| Abstract | We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p0.0001), tumor grade (p0.0324), and venous invasion (p0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC. |
| Keywords | nephroureterectomy transitional cell carcinoma upper urinary tract |
| Amo Type | Corrected and Republished Article |
| Published Date | 2011-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume65 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20200581 |
| Web of Science KeyUT | 000289818800011 |
| JaLCDOI | 10.18926/AMO/32878 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ebara, Shin| Manabe, Daisuke| Kobayashi, Yasuyuki| Tanimoto, Ryuta| Saika, Takashi| Nasu, Yasutomo| Saito, Shirou| Satoh, Takefumi| Miki, Kenta| Hashine, Katsuyoshi| Kumon, Hiromi| |
| Abstract | <p>From September 2003 to December 2005, 188 patients who visited our hospital and allied institutions for the purpose of prostate brachytherapy were administrated hormonal therapy for volume reductions before brachytherapy. The pretreatment and posttreatment of prostate volume using a transrectal ultrasound volumetric study and the types and duration of hormonal therapy were analyzed. We administered 91 patients with Luteinizing hormone-releasing hormone (LH-RH) agonist, 49 patients with anti-androgen (bicaltamide/flutamide), and 48 patients with maximum androgen blockade (MAB). The duration of the hormonal therapy was 1-3 months for 49 patients, 4-6 months for 59 patients, 7-9 months for 40 patients, 10-12 months for 32 patients, and over 13 months for 8 patients. Before the initiation of hormonal therapy, the mean prostate volume was 35.12 ml (11.04-78.71 ml), and the average of prostate volume before and after hormonal therapy was 36.79 ml and 24.79 ml, respectively (a 32.4% reduction). The prostate volume reduction rate was 32.0% for the LH-RH agonist only, 18.1% for the anti-androgen only and 41.2% for the MAB. No statistically significant difference was observed for the duration of hormonal therapy between 3 groups. A three-month course of the neoadjuvant LH-RH agonist indicated a sufficient volume reduction effectiveness for a large prostate volume.</p> |
| Keywords | androgen deprivation therapy brachytherapy localized prostate cancer prostate volume reduction |
| Amo Type | Original Article |
| Published Date | 2007-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume61 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 340 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 18183078 |
| Web of Science KeyUT | 000251943800004 |
