ID | 49251 |
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Author |
Nishimori, Hisakazu
Kaken ID
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Maeda, Yoshinobu
Kaken ID
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Abstract | Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Chronic GVHD often presents with clinical manifestations that resemble those observed in autoimmune diseases. Standard treatment is 1-2mg/kg/day of prednisone or an equivalent dose of methylprednisolone, with continued administration of a calcineurin inhibitor for steroid sparing. However, the prognosis of steroid-refractory chronic GVHD remains poor. Classically, chronic GVHD was said to involve predominantly Th2 responses. We are now faced with a more complex picture, involving possible roles for thymic dysfunction, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF), B cells and autoantibodies, and Th1/Th2/Th17 cytokines, as well as regulatory T cells (Tregs), in chronic GVHD. More detailed research on the pathophysiology of chronic GVHD may facilitate the establishment of novel strategies for its prevention and treatment.
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Keywords | chronic GVHD
Th17
Am80
regulatory T cell (Treg)
steroid-refractory
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Amo Type | Review
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Publication Title |
Acta Medica Okayama
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Published Date | 2013-02
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Volume | volume67
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 1
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End Page | 8
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
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