FullText URL fulltext.pdf
Author Taha, Eman A.| Sogawa, Chiharu| Okusha, Yuka| Kawai, Hotaka| Oo, May Wathone| Elseoudi, Abdellatif| Lu, Yanyin| Nagatsuka, Hitoshi| Kubota, Satoshi| Satoh, Ayano| Okamoto, Kuniaki| Eguchi, Takanori|
Keywords matrix metalloproteinase 3 (MMP3) extracellular vesicles (EVs) tumoroid tumor organoid tumorigenesis three-dimensional (3D) culture system
Published Date 2020-05-16
Publication Title Cancers
Volume volume12
Issue issue5
Publisher MDPI
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32429403
DOI 10.3390/cancers12051260
Web of Science KeyUT 000539246000201
Related Url isVersionOf https://doi.org/10.3390/cancers12051260
FullText URL fulltext.pdf
Author Ono, Sawako| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi|
Keywords YAP ΔNp63 oral epithelial dysplasia carcinoma in situ oral squamous cell carcinoma
Published Date 2019-05-28
Publication Title International Journal of Medical Sciences
Volume volume16
Issue issue5
Publisher Ivyspring International Publisher
Start Page 766
End Page 773
ISSN 1449-1907
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Ivyspring International Publisher.
File Version publisher
PubMed ID 31217745
DOI 10.7150/ijms.29995
Web of Science KeyUT 000534739100002
Related Url isVersionOf https://doi.org/10.7150/ijms.29995
FullText URL fulltext.pdf
Author Sukegawa, Shintaro | Kawai, Hotaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kanno, Takahiro| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
Keywords poly-L-lactide uncalcined and unsintered hydroxyapatite biocompatibility osteoconductivity mesenchymal stem cell
Published Date 2019-11-08
Publication Title Materials
Volume volume12
Issue issue22
Publisher MDPI
Start Page 3681
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31717278
DOI 10.3390/ma12223681
Web of Science KeyUT 000502284400038
Related Url isVersionOf https://doi.org/10.3390/ma12223681
FullText URL fulltext.pdf
Author Sukegawa, Shintaro| Kanno, Takahiro| Yamamoto, Norio| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
Keywords mandibular condylar fracture unsintered hydroxyapatite poly-l-lactide composite plate bioactive resorbable plate biomechanical loading evaluation fracture fixation
Published Date 2019-05-13
Publication Title Materials
Volume volume12
Issue issue9
Publisher MDPI
Start Page 1557
ISSN 1996-1944
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31085981
DOI 10.3390/ma12091557
Web of Science KeyUT 000469757500198
Related Url isVersionOf https://doi.org/10.3390/ma12091557
FullText URL IJO54_1_283.pdf
Author Shimizu, Rieko| Ibaragi, Soichiro| Eguchi, Takanori| Kuwajima, Daisuke| Kodama, Shinichi| Nishioka, Takashi| Okui, Tatsuo| Obata, Kyoichi| Takabatake, Kiyofumi| Kawai, Hotaka| Ono, Kisho| Okamoto, Kuniaki| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords nicotine head and neck squamous cell carcinoma lymph node metastasis cetuximab
Published Date 2018-11-12
Publication Title International Journal of Oncology
Volume volume54
Issue issue1
Publisher Spandidos Publications
Start Page 283
End Page 294
ISSN 1019-6439
NCID AA10992511
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 30431077
DOI 10.3892/ijo.2018.4631
Web of Science KeyUT 000451845400025
Related Url isVersionOf https://doi.org/10.3892/ijo.2018.4631
FullText URL IntJMolSci_20_8_1973.pdf
Author Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshida, Saori| Maeda, Hatsuhiko| Kawakami, Toshiyuki| Nagatsuka, Hitoshi|
Keywords cell differentiation epithelial-mesenchymal interaction immunohistochemistry malignant transformation notch signaling odontogenic tumor pleomorphic adenoma
Published Date 2019-04-23
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue8
Publisher MDPI
Start Page 1973
ISSN 14220067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31018488
DOI 10.3390/ijms20081973
Web of Science KeyUT 000467648700171
Related Url isVersionOf https://doi.org/10.3390/ijms20081973
JaLCDOI 10.18926/AMO/50408
FullText URL 67_3_153.pdf
Author Yamamoto, Masanao| Fujita, Hirofumi| Katase, Naoki| Inoue, Keiji| Nagatsuka, Hitoshi| Utsumi, Kozo| Sasaki, Junzo| Ohuchi, Hideyo|
Abstract Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum.
Keywords 5-aminolevulinic acid protoporphyrin IX oncology photodynamic therapy apoptosis
Amo Type Original Article
Published Date 2013-06
Publication Title Acta Medica Okayama
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 153
End Page 164
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804138
Web of Science KeyUT 000320747900004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/50681
Author Yanagi, Yoshinobu| Fujita, Mariko| Hisatomi, Miki| Matsuzaki, Hidenobu| Konouchi, Hironobu| Katase, Naoki| Nagatsuka, Hitoshi| Asaumi, Jun-ichi|
Published Date 201012
Publication Title Oral Radiology
Volume volume26
Issue issue2
Content Type Journal Article
Author Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
Published Date 2005-7
Publication Title Oral Oncology
Volume volume41
Issue issue10
Content Type Journal Article
Author Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
Published Date 2005-07
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume56
Issue issue1
Content Type Journal Article
Author Watanabe, Nobuyuki| Takaoka, Munenori| Sakurama, Kazufumi| Tomono, Yasuko| Hatakeyama, Shinji| Ohmori, Osamu| Motoki, Takayuki| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Haisa, Minoru| Matsuoka, Junji| Beer, David G.| Nagatsuka, Hitoshi| Tanaka, Noriaki| Naomoto, Yoshio|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
Author 長塚 仁|
Published Date 1991-03-28
Publication Title
Content Type Thesis or Dissertation