JaLCDOI 10.18926/AMO/54808
FullText URL 70_6_455.pdf
Author Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi|
Abstract Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
Keywords postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 455
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003670
Author Takeda, Yoshimasa| Kawashima, Takahisa| Kiyota, Kazuya| Oda, Shigeto| Morimoto, Naoki| Kobata, Hitoshi| Isobe, Hisashi| Honda, Mitsuru| Fujimi, Satoshi| Onda, Jun| I, Seishi| Sakamoto, Tetsuya| Ishikawa, Masami| Nakano, Hiroshi| Sadamitsu, Daikai| Kishikawa, Masanobu| Kinoshita, Kosaku| Yokoyama, Tomoharu| Harada, Masahiro| Kitaura, Michio| Ichihara, Kiyoshi| Hashimoto, Hiroshi| Tsuji, Hidekazu| Yorifuji, Takashi| Nagano, Osamu| Katayama, Hiroshi| Ujike, Yoshihito| Morita, Kiyoshi|
Published Date 2014-12
Publication Title Resuscitation
Volume volume85
Issue issue12
Content Type Journal Article
Author Tani, Makiko| Morimatsu, Hiroshi| Takatsu, Fumiaki| Morita, Kiyoshi|
Published Date 2012
Publication Title The Scientific World Journal
Volume volume2012
Content Type Journal Article
Author Kosaka, Junko| Morimatsu, Hiroshi| Takahashi, Toru| Shimizu, Hiroko| Kawanishi, Susumu| Omori, Emiko| Endo, Yasumasa| Tamaki, Naofumi| Morita, Manabu| Morita, Kiyoshi|
Published Date 2013-05-07
Publication Title PLoS ONE
Volume volume8
Issue issue5
Content Type Journal Article
Author Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi|
Published Date 2009-06
Publication Title 岡山歯学会雑誌
Volume volume28
Issue issue1
Content Type Journal Article
Author Danura, Tetsuya| Takeda, Yoshimasa| Shiraishi, Kensuke| Naito, Hiromichi| Mizoue, Ryoichi| Sato, Sachiko| Morita, Kiyoshi|
Published Date 2013-07
Publication Title Journal of Neurosurgical Anesthesiology
Volume volume25
Issue issue3
Content Type Journal Article
Author 縄稚 久美子| 曽我 賢彦| 山中 玲子| 足羽 孝子| 伊藤 真理| 佐藤 真千子| 窪木 拓男| 森田 潔|
Published Date 2012-07
Publication Title 日本集中治療医学会雑誌
Volume volume19
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/49039
FullText URL 66_6_435.pdf
Author Fujinaka, Waso| Shimizu, Juichiro| Iribe, Gentaro| Imaoka, Takeshi| Oshima, Yu| Kiyooka, Takahiko| Morita, Kiyoshi| Mohria, Satoshi|
Abstract Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-Vo2 (myocardial oxygen consumption per beat) relationship. We obtained 1) the Vo2-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the Vo2-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the Vo2-PVA relationship under increased intracoronary concentrations of either propofol or CaCl2 at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear Vo2-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent Vo2-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca2+. In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca2+ blockers or ß-antagonists—i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA.
Keywords anesthesia heart contractility myocardial oxygen consumption
Amo Type Original Article
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 435
End Page 442
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254577
Web of Science KeyUT 000312966100002
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/49732
JaLCDOI 10.18926/AMO/48569
FullText URL 66_3_285.pdf
Author Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi|
Abstract Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.
Keywords beta-blocker landiolol formalin pain behavior c-fos
Amo Type Original Article
Published Date 2012-06
Publication Title Acta Medica Okayama
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 285
End Page 289
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729110
Web of Science KeyUT 000305669700013