FullText URL fulltext.pdf
Author Katsuyama, Eri| Miyawaki, Yoshia| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Hiramatsu-Asano, Sumie| Morishita, Michiko| Ohashi, Keiji| Watanabe, Haruki| Katsuyama, Takayuki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun|
Keywords Lupus nephritis Active lesions Chronic lesions Urinary protein Serum creatinine
Published Date 2020-06-01
Publication Title BMC Nephrology
Volume volume21
Issue issue1
Publisher BMC
Start Page 208
ISSN 1471-2369
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32487161
DOI 10.1186/s12882-020-01868-9
Web of Science KeyUT 000538054600002
Related Url isVersionOf https://doi.org/10.1186/s12882-020-01868-9
JaLCDOI 10.18926/AMO/59949
FullText URL 74_3_191.pdf
Author Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun|
Abstract Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
Keywords systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type Original Article
Published Date 2020-06
Publication Title Acta Medica Okayama
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 198
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577016
FullText URL SR9_1_3054.pdf
Author Hiramatsu, Sumie| Watanabe, Katsue S.| Zeggar, Sonia| Asano, Yosuke| Miyawaki, Yoshia| Yamamura, Yuriko| Katsuyama, Eri| Katsuyama, Takayuki| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Kawabata, Tomoko| Sada, Ken-Ei| Wada, Jun|
Published Date 2019-2-28
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 3054
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version Publisher
PubMed ID 30816218
DOI 10.1038/s41598-019-38809-y
Web of Sience KeyUT 000459891700064
Related Url isVersionOf https://doi.org/10.1038/s41598-019-38809-y