このエントリーをはてなブックマークに追加
ID 46635
JaLCDOI
FullText URL
Author
Waseda, Koichi
Tanimoto, Yasushi Kaken ID researchmap
Nojima, Daisuke
Ikeda, Genyo
Okada, Chiharu
Abstract
Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare. We report a case of CSS with necrosis of the toe tips. A 37-year-old woman with asthma, who had been diagnosed with CSS 2 years ago, was admitted to our hospital with an exacerbation of CSS. The patient had a high grade fever and complained of abdominal pain and numbness of the lower extremities. Blood examination revealed marked eosinophilia. The fever pattern, abdominal pain and blood eosinophilia showed improvement by combination treatment with prednisolone and cyclophosphamide. However, the color of her right toe tips changed, and necrosis finally resulted despite antithrombotic therapy. Arteriography showed narrowing of the dorsalis pedis artery and of the more peripheral arteries of her right leg. Stump plasty with negative pressure dressing therapy for the toe tips, but not amputation, was done to preserve the leg function. While numbness of the extremities remained, no recurrence of necrosis was seen. Clinicians need to be aware that rare complications of CSS, including necrosis of the digits, can occur.
Keywords
bronchial asthma
Churg-Strauss syndrome
eosinophilia
necrosis of toe tips
stump plasty
Amo Type
Case Report
Published Date
2011-06
Publication Title
Acta Medica Okayama
Volume
volume65
Issue
issue3
Publisher
Okayama University Medical School
Start Page
215
End Page
218
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2011 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT