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ID 31331
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Author
Kawakami, Yasuhiro
Suemaru, Katsuya
Araki, Hiroaki
Kawasaki, Hiromu Kaken ID publons
Gomita, Yutaka
Tanizaki, Yoshiro
Abstract

The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretreated control group. MAP (10 mg/kg, p.o.)-induced stereotyped behavior on the 8th day was also greater in MZD-pretreated group rather than the saline-pretreated control group. These results suggest that repeated MZD and MAP administration cross-sensitizes to their stereotype-producing effects.

Keywords
mazindoi
methamphetamine
cross-sensitization
stereotyped behavior
Amo Type
Article
Published Date
1998-06
Publication Title
Acta Medica Okayama
Volume
volume52
Issue
issue3
Publisher
Okayama University Medical School
Start Page
169
End Page
171
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT