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ID 31328
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Author
Suemaru, Katsuya
Kawasaki, Hiromu Kaken ID publons
Yasuhara, Kanako
Yao, Kazuhisa
Furuno, Katusushi
Kawakami, Yasuhiro
Araki, Hiroaki
Gomita, Yutaka
Oka, Eiji
Abstract

Steady-state serum concentrations of carbamazepine (CBZ) and valproic acid (VPA) were investigated in normal weight (body mass index; BMI 20 to 25), lean (smaller than 20 BMI) and moderately obese subjects (greater than 25 BMI) who received either 400 mg/day of CBZ or 800 mg/day of VPA. The CBZ serum concentration in lean subjects was significantly higher than that in normal weight subjects. However, no significant differences in VPA serum concentration were found between the three groups. The CBZ serum concentration decreased with increases in total body weight, and the VPA serum concentration decreased with increases in ideal body weight. However, both serum concentrations were not correlated with BMI. These results suggest that VPA doses should be calculated using ideal body weight and that degree of obesity may affect CBZ serum concentration rather than VPA serum concentration.

Keywords
carbamazepine
valproic acid
serum concentration
obesity
lean
Amo Type
Article
Published Date
1998-06
Publication Title
Acta Medica Okayama
Volume
volume52
Issue
issue3
Publisher
Okayama University Medical School
Start Page
139
End Page
142
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT