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ID 30470
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Author
Watanabe, Kazuhide
Matsuka, Naoyuki
Furuno, Katushi
Eto, Kohei
Kawasaki, Hiromu Kaken ID publons
Gomita, Yutaka
Abstract

In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.

Keywords
omeprazole
suspension
pharmacokinetics
rats
Amo Type
Article
Published Date
1996-08
Publication Title
Acta Medica Okayama
Volume
volume50
Issue
issue4
Publisher
Okayama University Medical School
Start Page
219
End Page
222
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT