このエントリーをはてなブックマークに追加
ID 60701
FullText URL
Thumnail fultext.pdf 945 KB
Author
Ho, Dung Thi Graduate School of Environmental and Life Science, Okayama University
Hatabu, Toshimitsu Graduate School of Environmental and Life Science, Okayama University Kaken ID researchmap
Sunada, Yosuke Research & Development, Ohayo Dairy Products Co., Ltd.
Kondo, Yasuhiro Graduate School of Environmental and Life Science, Okayama University Kaken ID publons researchmap
Abstract
Probiotic supplements containing living bacteria have attracted interest as a potential source of health benefits for humans and livestock. The aim of this study was to determine whether administration of Lactobacillus acidophilus strain L-55 (LaL-55) enhances the immune response among chicks exposed to a Newcastle disease virus (NDV)-based live attenuated vaccine. Oral administration of LaL-55 augmented the elevation in the total numbers of leukocytes and lymphocytes following inoculation with the NDV-based live attenuated vaccine. Monocyte counts increased after LaL-55 administration independent of inoculation with the NDV vaccine. Among chicks that were administered LaL-55, there was a dose-dependent increase in the NK cell activity measured by a 51Cr release assay at 2 weeks after the secondary NDV vaccine inoculation. Two weeks after the secondary inoculation with the NDV vaccine, interferon (IFN)-γ-mRNA expression was significantly elevated in mononuclear splenocytes from chicks that were administered LaL-55. Meanwhile, LaL-55 administration did not change the mRNA levels of IFN-α, IFN-β, and interleukin-1β. These results may suggest that coadministration of LaL-55 with an NDV vaccine augments the immune response against the virus. Therefore, LaL-55 may help protect against viral diseases in poultry.
Keywords
Lactobacillus acidophilus L-55
chicken
Newcastle disease vaccine
immunomodulatory
Published Date
2020-02-27
Publication Title
Bioscience of Microbiota, Food and Health
Volume
volume39
Issue
issue3
Publisher
BMFH Press
Start Page
117
End Page
122
ISSN
21866953
NCID
AA12588288
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
©2020 BMFH Press
File Version
publisher
PubMed ID
NAID
DOI
Web of Science KeyUT
Related Url
isVersionOf https:www.doi.org/10.12938/bmfh.2019-033
License
https://creativecommons.org/licenses/by-nc-nd/4.0/