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ID 58230
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Hatabu, Toshimitsu Laboratory of Animal Physiology, Graduate School of Environmental and Life Science , Okayama University Kaken ID researchmap
Harada, Takumi Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Takao, Yuri Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Dung, Ho Thi Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Yamasato, Akihiro K.I Chemical Industry Co., Ltd.
Horiuchi, Tatsuya K.I Chemical Industry Co., Ltd.
Mochizuki, Atsuya K.I Chemical Industry Co., Ltd.
Kondo, Yasuhiro Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University Kaken ID publons researchmap
Abstract
The aim of this study was to investigate the effects of egg yolk powder enriched with astaxanthin (ASX-E) on blood pressure in spontaneously hypertensive rats (SHR) and to verify the benefits of ASX-E as a functional food. To investigate the antihypertensive effect, SHR were fed with an ASX-E mixed diet before hypertension development. Blood pressures were determined periodically during the study by the tail-cuff method. At the end of the study, animals were euthanized, and their thoracic aortas were collected to determine vascular conductance. The thoracic aorta tension was measured with a force displacement transducer. Concentration-dependent response relationships were determined by cumulative addition of 10−9–10−4 M Carbamoylcholine (Cch). Blood pressures of the SHR in the ASX-E mixed diet group were ASX-dose-dependently lower than that of those in the control group. In SHR fed with an ASX-E mixed diet, Cch induced vasorelaxation in the thoracic aorta with endothelium lining but not without endothelium. However, the antihypertensive effect of ASX-E was not observed on blood pressures in SHR that were fed with ASX-E only after the development of hypertension. Results suggest that ASX-E protects endothelial function and thereby prevents the development of hypertension. Hence, the results of our research indicate that daily consumption of ASX-E has a potential benefit on human health.
Keywords
astaxanthin-enriched egg yolk
hypertension
spontaneously hypertensive rat
Published Date
2020-03-01
Publication Title
Biological and Pharmaceutical Bulletin
Volume
volume43
Issue
issue3
Publisher
The Pharmaceutical Society of Japan
Start Page
404
End Page
408
ISSN
0918-6158
NCID
AA10885497
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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Publisher
PubMed ID
NAID
DOI
Web of Science KeyUT
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isVersionOf https://doi.org/10.1248/bpb.b19-01013