BPB_43_404.pdf 480 KB
Hatabu, Toshimitsu Laboratory of Animal Physiology, Graduate School of Environmental and Life Science , Okayama University Kaken ID researchmap
Harada, Takumi Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Takao, Yuri Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Dung, Ho Thi Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
Yamasato, Akihiro K.I Chemical Industry Co., Ltd.
Horiuchi, Tatsuya K.I Chemical Industry Co., Ltd.
Mochizuki, Atsuya K.I Chemical Industry Co., Ltd.
The aim of this study was to investigate the effects of egg yolk powder enriched with astaxanthin (ASX-E) on blood pressure in spontaneously hypertensive rats (SHR) and to verify the benefits of ASX-E as a functional food. To investigate the antihypertensive effect, SHR were fed with an ASX-E mixed diet before hypertension development. Blood pressures were determined periodically during the study by the tail-cuff method. At the end of the study, animals were euthanized, and their thoracic aortas were collected to determine vascular conductance. The thoracic aorta tension was measured with a force displacement transducer. Concentration-dependent response relationships were determined by cumulative addition of 10−9–10−4 M Carbamoylcholine (Cch). Blood pressures of the SHR in the ASX-E mixed diet group were ASX-dose-dependently lower than that of those in the control group. In SHR fed with an ASX-E mixed diet, Cch induced vasorelaxation in the thoracic aorta with endothelium lining but not without endothelium. However, the antihypertensive effect of ASX-E was not observed on blood pressures in SHR that were fed with ASX-E only after the development of hypertension. Results suggest that ASX-E protects endothelial function and thereby prevents the development of hypertension. Hence, the results of our research indicate that daily consumption of ASX-E has a potential benefit on human health.
astaxanthin-enriched egg yolk
spontaneously hypertensive rat
Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan
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