JaLCDOI 10.18926/AMO/32888
FullText URL fulltext.pdf
Author Yasuhara, Takao| Shingo, Tetsuro| Date, Isao|
Abstract <p>Many studies using animals clarify that glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic neurons. Several pilot studies clarified the validity of continuous intraputaminal GDNF infusion to patients with Parkinson's disease (PD), although a randomized controlled trial of GDNF therapy published in 2006 resulted in negative outcomes, and controversy remains about the efficacy and safety of the treatment. For a decade, our laboratory has investigated the efficacy and the most appropriate method of GDNF administration using animals, and consequently we have obtained some solid data that correspond to the results of clinical trials. In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future.</p>
Keywords cell transplantation clinical trial encapsulation gene therapy neurodegenerative disease
Amo Type Review
Published Date 2007-04
Publication Title Acta Medica Okayama
Volume volume61
Issue issue2
Publisher Okayama University Medical School
Start Page 51
End Page 56
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17471304
Web of Science KeyUT 000245875600001
JaLCDOI 10.18926/AMO/43832
FullText URL 65_1_59.pdf
Author Yasuhara, Takao| Miyoshi, Yasuyuki| Date, Isao|
Abstract A case of a Chiari malformation with an extraordinarily thick occipital bone is described. The thick occipital bone might make the posterior fossa narrow with consequent herniation of the cerebellar tonsils to the foramen magnum and formation of a syrinx. At dural plasty, well-developed marginal and occipital sinuses should be deliberately handled with the preservation of normal venous drainage. This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression.
Keywords Chiari malformation dural plasty foramen magnum decompression syrinx venous drainage
Amo Type Case Report
Published Date 2011-02
Publication Title Acta Medica Okayama
Volume volume65
Issue issue1
Publisher Okayama University Medical School
Start Page 59
End Page 61
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21339798
Web of Science KeyUT 000287620500009
JaLCDOI 10.18926/AMO/48962
FullText URL 66_6_429.pdf
Author Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke|
Abstract Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
Keywords umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type Review
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 429
End Page 434
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254576
Web of Science KeyUT 000312966100001
JaLCDOI 10.18926/AMO/49045
FullText URL 66_6_487.pdf
Author Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao|
Abstract We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
Keywords periventricular nodular heterotopia epilepsy surgery ictal electroencephalography
Amo Type Case Report
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 487
End Page 492
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254583
Web of Science KeyUT 000312966100008
JaLCDOI 10.18926/AMO/54497
FullText URL 70_4_229.pdf
Author Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao|
Abstract About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.
Keywords clinical research moyamoya disease
Amo Type Review
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 229
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549666
Web of Science KeyUT 000384748600001
JaLCDOI 10.18926/AMO/55201
FullText URL 71_3_191.pdf
Author Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
Abstract  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
Keywords fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655938
FullText URL Acta_Neurochir_159_7_1329.pdf
Author Kidani, Naoya| Sugiu, Kenji| Hishikawa, Tomohito| Hiramatsu, Masafumi| Haruma, Jun| Nishihiro, Shingo| Takahashi, Yu| Date, Isao|
Keywords De novo aneurysm Hemodynamic stress Stent-assisted coil embolization Vertebral artery dissecting aneurysm
Published Date 2017-07
Publication Title Acta Neurochirurgica
Volume volume159
Issue issue7
Publisher Springer
Start Page 1329
End Page 1333
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28493024
Web of Science KeyUT 000403508400024
Related Url https://doi.org/10.1007/s00701-017-3204-2
Author Hishikawa, Tomohito| Sugiu, Kenji| Murai, Satoshi| Takahashi, Yu| Kidani, Naoya| Nishihiro, Shingo| Hiramatsu, Masafumi| Date, Isao| Satow, Tetsu| Iihara, Koji| Sakai, Nobuyuki| JR-NET2 and JR-NET3 study groups.|
Keywords Complication Embolization Intracranial tumor Risk factors
Note This fulltext will be available in Aug 2020|
Published Date 2019-06-07
Publication Title Acta Neurochirurgica
Volume volume161
Issue issue8
Publisher Springer Nature
Start Page 1675
End Page 1682
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31172282
DOI 10.1007/s00701-019-03970-w
Web of Science KeyUT 000475688800023
Related Url isVersionOf https://doi.org/10.1007/s00701-019-03970-w
Title Alternative Adult neural stem and progenitor cell transplantation in CNS diseases
FullText URL 120_153.pdf
Author Kameda, Masahiro| Shingo, Tetsuro| Muraoka, Kenichiro| Takahashi, Kazuya| Yasuhara, Takao| Date, Isao|
Keywords 成体由来神経幹細胞 脳内移植 グリア細胞株由来神経栄養因子(GDNF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 153
End Page 157
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.153
NAID 120002310550
FullText URL 118_99.pdf
Author 安原 隆雄| 新郷 哲郎| 小林 和樹| 竹内 亮| 矢野 昭正| 村岡 賢一郎| 亀田 雅博| 元 文姫| 早瀬 仁志| 上利 崇| 松井 利浩| 三好 康之| 伊達 勲|
Keywords カプセル化細胞移植 グリア細胞株由来神経栄養因子 (GDNF) 血管内皮成長因子 (VEGF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2006-09-01
Volume volume118
Issue issue2
Start Page 99
End Page 103
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.2_99
NAID 10018059355
FullText URL 115_145.pdf
Author 松井 利浩| 伊達 勲|
Keywords neuroendoscope neurosurgery hydrocephalus third ventriculostomy biopsy
Publication Title 岡山医学会雑誌
Published Date 2005-09-30
Volume volume115
Issue issue2
Start Page 145
End Page 150
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.115.2_145
NAID 10011896852
Title Alternative Parkinson's disease from a viewpoint of regenerative medicine
FullText URL 116_17.pdf
Author Date, Isao|
Abstract It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.
Keywords Parkinson's disease neural transplantation regeneration
Publication Title 岡山医学会雑誌
Published Date 2004-05-31
Volume volume116
Issue issue1
Start Page 17
End Page 27
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.116.1_17
NAID 10013089196
Title Alternative Hosting the 16th Annual Meeting of the Japanese Society for Normal Pressure Hydrocephalus
FullText URL 127_259.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 259
End Page 260
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.259
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.259
NAID 130005116806
Title Alternative Hosting the 18th JASMEE Academic Meeting in Okayama
FullText URL 128_69.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 69
End Page 70
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.69
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.69
NAID 120005752921
FullText URL K000871.pdf
Author Date, Isao|
Keywords MHC locus immune reactions
Published Date 1990-09-30
Content Type Thesis or Dissertation
Grant Number 甲第871号
Granted Date 1990-09-30
Thesis Type 博士(医学)
Grantor 岡山大学
language 日本語
Author Wang, Feifei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Date, Isao|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Article
Author Hayase, Hitoshi| Tokunaga, Koji| Nakayama, Toshio| Sugiu, Kenji| Nishida, Ayumi| Arimitsu, Seiji| Hishikawa, Tomohito| Ono, Shigeki| Ohta, Makoto| Date, Isao|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
Author Okuma, Yu| Liu, Keyue| Wake, Hidenori| Haruma, Jun| Yoshino, Tadashi| Ohtsuka, Aiji| Takahashi, Hideo| Mori, Shuji| Nishibori, Masahiro| Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Article