Author Hayase, Hitoshi| Tokunaga, Koji| Nakayama, Toshio| Sugiu, Kenji| Nishida, Ayumi| Arimitsu, Seiji| Hishikawa, Tomohito| Ono, Shigeki| Ohta, Makoto| Date, Isao|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
FullText URL 118_205.pdf
Author 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲|
Keywords プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン
Publication Title 岡山医学会雑誌
Published Date 2007-01-04
Volume volume118
Issue issue3
Start Page 205
End Page 208
ISSN 00301558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.3_205
NAID 10018454083
Author Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Article
Author Date, Isao|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Article
Title Alternative Hosting the 18th JASMEE Academic Meeting in Okayama
FullText URL 128_69.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 69
End Page 70
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.69
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.69
NAID 120005752921
Title Alternative Hosting the 16th Annual Meeting of the Japanese Society for Normal Pressure Hydrocephalus
FullText URL 127_259.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 259
End Page 260
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.259
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.259
NAID 130005116806
FullText URL 115_145.pdf
Author 松井 利浩| 伊達 勲|
Keywords neuroendoscope neurosurgery hydrocephalus third ventriculostomy biopsy
Publication Title 岡山医学会雑誌
Published Date 2005-09-30
Volume volume115
Issue issue2
Start Page 145
End Page 150
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.115.2_145
NAID 10011896852
Author Okuma, Yu| Liu, Keyue| Wake, Hidenori| Haruma, Jun| Yoshino, Tadashi| Ohtsuka, Aiji| Takahashi, Hideo| Mori, Shuji| Nishibori, Masahiro| Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Title Alternative Parkinson's disease from a viewpoint of regenerative medicine
FullText URL 116_17.pdf
Author Date, Isao|
Abstract It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.
Keywords Parkinson's disease neural transplantation regeneration
Publication Title 岡山医学会雑誌
Published Date 2004-05-31
Volume volume116
Issue issue1
Start Page 17
End Page 27
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.116.1_17
NAID 10013089196
Title Alternative Adult neural stem and progenitor cell transplantation in CNS diseases
FullText URL 120_153.pdf
Author Kameda, Masahiro| Shingo, Tetsuro| Muraoka, Kenichiro| Takahashi, Kazuya| Yasuhara, Takao| Date, Isao|
Keywords 成体由来神経幹細胞 脳内移植 グリア細胞株由来神経栄養因子(GDNF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 153
End Page 157
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.153
NAID 120002310550
FullText URL 118_99.pdf
Author 安原 隆雄| 新郷 哲郎| 小林 和樹| 竹内 亮| 矢野 昭正| 村岡 賢一郎| 亀田 雅博| 元 文姫| 早瀬 仁志| 上利 崇| 松井 利浩| 三好 康之| 伊達 勲|
Keywords カプセル化細胞移植 グリア細胞株由来神経栄養因子 (GDNF) 血管内皮成長因子 (VEGF) 脳虚血 パーキンソン病
Publication Title 岡山医学会雑誌
Published Date 2006-09-01
Volume volume118
Issue issue2
Start Page 99
End Page 103
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.2_99
NAID 10018059355
Author Wang, Feifei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Author Kosaka, H| Ichikawa, T| Kurozumi, K| Kambara, H| Inoue, S| Maruo, T| Nakamura, K| Hamada, H| Date, I|
Published Date 2012-08
Publication Title Cancer Gene Therapy
Volume volume19
Issue issue8
Content Type Journal Article
Author Tayra, Judith Thomas| Kameda, Masahiro| Yasuhara, Takao| Agari, Takashi| Kadota, Tomohito| Wang, Feifei| Kikuchi, Yoichiro| Liang, Hanbai| Shinko, Aiko| Wakamori, Takaaki| Vcelar, Brigitta| Weik, Robert| Date, Isao|
Published Date 2013-03-28
Publication Title Brain Research
Volume volume1502
Content Type Journal Article
Author Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I|
Published Date 2013-08
Publication Title Cancer Gene Therapy
Volume volume20
Issue issue8
Content Type Journal Article
JaLCDOI 10.18926/AMO/48962
FullText URL 66_6_429.pdf
Author Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke|
Abstract Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
Keywords umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type Review
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 429
End Page 434
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254576
Web of Science KeyUT 000312966100001
JaLCDOI 10.18926/AMO/54813
FullText URL 70_6_493.pdf
Author Yasuhara, Takao| Kuwahara, Ken| Sasada, Susumu| Toyoshima, Atsuhiko| Morimoto, Jun| Kin, Kyohei| Manabe, Hiroaki| Miyoshi, Yasuyuki| Kusumegi, Akira| Takahashi, Yuichiro| Ito, Kiyoshi| Date, Isao|
Abstract Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support.
Keywords Achilles tendon rupture electromyogram genuflection injured leg standing position
Amo Type Short Communication
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 493
End Page 496
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003675
JaLCDOI 10.18926/AMO/49045
FullText URL 66_6_487.pdf
Author Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao|
Abstract We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
Keywords periventricular nodular heterotopia epilepsy surgery ictal electroencephalography
Amo Type Case Report
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 487
End Page 492
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254583
Web of Science KeyUT 000312966100008
JaLCDOI 10.18926/AMO/55201
FullText URL 71_3_191.pdf
Author Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
Abstract  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
Keywords fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655938