JaLCDOI 10.18926/AMO/31858
FullText URL fulltext.pdf
Author Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
Abstract <p>Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this &#34;11R&#34;, all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).</p>
Keywords cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP)
Amo Type Review
Published Date 2009-02
Publication Title Acta Medica Okayama
Volume volume63
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 7
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19247417
Web of Science KeyUT 000263730300001
Title Alternative Novel protein transduction method for cerebral arteries using 11R
FullText URL 120_129.pdf
Author Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
Keywords cerebral vasospasm 11R protein transduction method
Publication Title 岡山医学会雑誌
Published Date 2008-08-01
Volume volume120
Issue issue2
Start Page 129
End Page 133
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.129
NAID 120002310545
FullText URL 118_205.pdf
Author 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲|
Keywords プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン
Publication Title 岡山医学会雑誌
Published Date 2007-01-04
Volume volume118
Issue issue3
Start Page 205
End Page 208
ISSN 00301558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.3_205
NAID 10018454083
Author Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Author Kosaka, H| Ichikawa, T| Kurozumi, K| Kambara, H| Inoue, S| Maruo, T| Nakamura, K| Hamada, H| Date, I|
Published Date 2012-08
Publication Title Cancer Gene Therapy
Volume volume19
Issue issue8
Content Type Journal Article
Author Iwado, Eiji| Ichikawa, Tomotsugu| Kosaka, Hiroshi| Otsuka, Shinji| Kambara, Hirokazu| Tamiya, Takashi| Kondo, Seiji| Date, Isao|
Published Date 2012-12
Publication Title Neuropathology
Volume volume32
Issue issue6
Content Type Journal Article
Author Maruo, Tomoko| Ichikawa, Tomotsugu| Kanzaki, Hirotaka| Inoue, Satoshi| Kurozumi, Kazuhiko| Onishi, Manabu| Yoshida, Koichi| Kambara, Hirokazu| Ouchida, Mamoru| Shimizu, Kenji| Tamaru, Seiji| Chiocca, E. Antonio| Date, Isao|
Published Date 2013-06
Publication Title Neuropathology
Volume volume33
Issue issue3
Content Type Journal Article
Author Onishi, Manabu| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Fujii, Kentaro| Yoshida, Koichi| Inoue, Satoshi| Michiue, Hiroyuki| Chiocca, E. Antonio| Kaur, Balveen| Date, Isao|
Published Date 2013-04
Publication Title Neuropathology
Volume volume33
Issue issue2
Content Type Journal Article
Author Ishida, Joji| Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Fujii, Kentaro| Shimazu, Yosuke| Oka, Tetsuo| Date, Isao|
Published Date 2014-04
Publication Title Translational Oncology
Volume volume7
Issue issue2
Content Type Journal Article
Author Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao|
Published Date 2013-04-15
Publication Title SpringerPlus
Volume volume2
Content Type Journal Article
FullText URL fulltext.pdf
Author Tomita, Yusuke| Fujii, Kentaro| Kurozumi, Kazuhiko| Imoto, Ryoji| Mitsui, Takashi| Mishima, Sakurako| Inagaki, Kenichi| Masuyama, Hisashi| Date, Isao|
Keywords Optic nerve Cavernous hemangioma Pregnant Visual evoked potential
Published Date 2019-12-31
Publication Title Interdisciplinary Neurosurgery
Volume volume18
Publisher Elsevier
Start Page 100489
ISSN 22147519
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier B.V.
File Version publisher
DOI 10.1016/j.inat.2019.100489
Web of Science KeyUT 000499495300012
Related Url isVersionOf https://doi.org/10.1016/j.inat.2019.100489
JaLCDOI 10.18926/AMO/32888
FullText URL fulltext.pdf
Author Yasuhara, Takao| Shingo, Tetsuro| Date, Isao|
Abstract <p>Many studies using animals clarify that glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic neurons. Several pilot studies clarified the validity of continuous intraputaminal GDNF infusion to patients with Parkinson's disease (PD), although a randomized controlled trial of GDNF therapy published in 2006 resulted in negative outcomes, and controversy remains about the efficacy and safety of the treatment. For a decade, our laboratory has investigated the efficacy and the most appropriate method of GDNF administration using animals, and consequently we have obtained some solid data that correspond to the results of clinical trials. In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future.</p>
Keywords cell transplantation clinical trial encapsulation gene therapy neurodegenerative disease
Amo Type Review
Published Date 2007-04
Publication Title Acta Medica Okayama
Volume volume61
Issue issue2
Publisher Okayama University Medical School
Start Page 51
End Page 56
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17471304
Web of Science KeyUT 000245875600001
JaLCDOI 10.18926/AMO/43832
FullText URL 65_1_59.pdf
Author Yasuhara, Takao| Miyoshi, Yasuyuki| Date, Isao|
Abstract A case of a Chiari malformation with an extraordinarily thick occipital bone is described. The thick occipital bone might make the posterior fossa narrow with consequent herniation of the cerebellar tonsils to the foramen magnum and formation of a syrinx. At dural plasty, well-developed marginal and occipital sinuses should be deliberately handled with the preservation of normal venous drainage. This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression.
Keywords Chiari malformation dural plasty foramen magnum decompression syrinx venous drainage
Amo Type Case Report
Published Date 2011-02
Publication Title Acta Medica Okayama
Volume volume65
Issue issue1
Publisher Okayama University Medical School
Start Page 59
End Page 61
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21339798
Web of Science KeyUT 000287620500009
JaLCDOI 10.18926/AMO/48962
FullText URL 66_6_429.pdf
Author Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke|
Abstract Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
Keywords umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type Review
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 429
End Page 434
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254576
Web of Science KeyUT 000312966100001
JaLCDOI 10.18926/AMO/49045
FullText URL 66_6_487.pdf
Author Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao|
Abstract We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
Keywords periventricular nodular heterotopia epilepsy surgery ictal electroencephalography
Amo Type Case Report
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 487
End Page 492
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254583
Web of Science KeyUT 000312966100008
JaLCDOI 10.18926/AMO/54497
FullText URL 70_4_229.pdf
Author Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao|
Abstract About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.
Keywords clinical research moyamoya disease
Amo Type Review
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 229
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549666
Web of Science KeyUT 000384748600001
JaLCDOI 10.18926/AMO/55201
FullText URL 71_3_191.pdf
Author Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
Abstract  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
Keywords fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655938
FullText URL Acta_Neurochir_159_7_1329.pdf
Author Kidani, Naoya| Sugiu, Kenji| Hishikawa, Tomohito| Hiramatsu, Masafumi| Haruma, Jun| Nishihiro, Shingo| Takahashi, Yu| Date, Isao|
Keywords De novo aneurysm Hemodynamic stress Stent-assisted coil embolization Vertebral artery dissecting aneurysm
Published Date 2017-07
Publication Title Acta Neurochirurgica
Volume volume159
Issue issue7
Publisher Springer
Start Page 1329
End Page 1333
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28493024
Web of Science KeyUT 000403508400024
Related Url https://doi.org/10.1007/s00701-017-3204-2
Author Hishikawa, Tomohito| Sugiu, Kenji| Murai, Satoshi| Takahashi, Yu| Kidani, Naoya| Nishihiro, Shingo| Hiramatsu, Masafumi| Date, Isao| Satow, Tetsu| Iihara, Koji| Sakai, Nobuyuki| JR-NET2 and JR-NET3 study groups.|
Keywords Complication Embolization Intracranial tumor Risk factors
Note This fulltext will be available in Aug 2020|
Published Date 2019-06-07
Publication Title Acta Neurochirurgica
Volume volume161
Issue issue8
Publisher Springer Nature
Start Page 1675
End Page 1682
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31172282
DOI 10.1007/s00701-019-03970-w
Web of Science KeyUT 000475688800023
Related Url isVersionOf https://doi.org/10.1007/s00701-019-03970-w
FullText URL fulltext.pdf
Author Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Otani, Yoshihiro| Fujimura, Atsushi| Fujii, Kentaro| Tomita, Yusuke| Hattori, Yasuhiko| Uneda, Atsuhito| Tsuboi, Nobushige| Kaneda, Keisuke| Makino, Keigo| Date, Isao|
Keywords ANXA2 OSMR Invasion Mesenchymal transition Glioblastoma
Published Date 2020-04-05
Publication Title Acta Neuropathologica Communications
Volume volume8
Issue issue1
Publisher BMC
Start Page 42
ISSN 2051-5960
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32248843
DOI 10.1186/s40478-020-00916-7
Web of Science KeyUT 000524286500001
Related Url isVersionOf https://doi.org/10.1186/s40478-020-00916-7