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Kin, Kyohei Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID
Yasuhara, Takao Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID researchmap
Kameda, Masahiro Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID researchmap
Date, Isao Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Abstract
Parkinson's disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.
Keywords
animal model
alpha-synuclein
DJ-1
neurotoxin
Parkin
Parkinson's disease
pesticide
PINK1
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
6-hydroxydopamine
Published Date
2019-10-30
Publication Title
International Journal of Molecular Sciences
Volume
volume20
Issue
issue21
Publisher
MDPI
Start Page
E5402
ISSN
1422-0067
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 by the authors.
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publisher
PubMed ID
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Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3390/ijms20215402
License
http://creativecommons.org/licenses/by/4.0/