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ID 30766
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Author
Iwagaki, Hiromi
Hizuta, Akio
Uomoto, Masashi
Takeuchi, Yoshiaki
Tanaka, Noriaki
Abstract

Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.

Keywords
cancer cachexia
neuro-endocrine-immune interactio
serotonin
neopterin
cortisol
Amo Type
Article
Published Date
1997-08
Publication Title
Acta Medica Okayama
Volume
volume51
Issue
issue4
Publisher
Okayama University Medical School
Start Page
233
End Page
236
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT