ID | 14010 |
Eprint ID | 14010
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FullText URL | |
Title Alternative | Measurement of cyclosporine concentration using radioimmunoassay with a specific monoclonal antibody : Preparing for the liver transplantation program in Okayama University Medical School
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Author |
Sakagami, Kenichi
Matsuno, Tsuyoshi
Orita, Kunzo
Akiyama, Takao
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Abstract | Cyclosporine, a new strong immunosuppressive agent, has dramatically improved the outcome of liver transplantation since its introduction to the clinical field in the 1980s.
Despite its efficacy, cyclosporine has a very narrow therapeutic window, wthich requires fine adjustment of the appropriate dose based on its concentration in the blood.
It will be necessary to obtain reliable data on a daily basis, when the liver transplantation program actually starts in the near future. To address this problem, we examined the utility of the radioimmunoassay kit using a specific monoclonal antibody (CYCLO-Trac WHOLE-BLOOD, Baxter, Japan), compared with the data derived from a commercial laboratory service (SRL, Japan). Each value of the cyclosporine concentration in the whole blood, measurely by CYCLO-Trac correlated with that of SRL(p<0.0001). CYCLO-Trac was suggested to be useful in obtaining a reliable data on a daily basis within our hospital.
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Keywords | シクロスポリン
モノクロナル抗体
ラジオイムノアッセイ法
腎移植
肝移植
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Published Date | 1993-02-27
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume105
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Issue | issue1-2
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 227
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End Page | 229
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_227/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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