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ID 14010
Eprint ID
14010
FullText URL
105_227.pdf 95.7 KB
Title Alternative
Measurement of cyclosporine concentration using radioimmunoassay with a specific monoclonal antibody : Preparing for the liver transplantation program in Okayama University Medical School
Author
Sakagami, Kenichi
Matsuno, Tsuyoshi
Orita, Kunzo
Akiyama, Takao
Abstract
Cyclosporine, a new strong immunosuppressive agent, has dramatically improved the outcome of liver transplantation since its introduction to the clinical field in the 1980s. Despite its efficacy, cyclosporine has a very narrow therapeutic window, wthich requires fine adjustment of the appropriate dose based on its concentration in the blood. It will be necessary to obtain reliable data on a daily basis, when the liver transplantation program actually starts in the near future. To address this problem, we examined the utility of the radioimmunoassay kit using a specific monoclonal antibody (CYCLO-Trac WHOLE-BLOOD, Baxter, Japan), compared with the data derived from a commercial laboratory service (SRL, Japan). Each value of the cyclosporine concentration in the whole blood, measurely by CYCLO-Trac correlated with that of SRL(p<0.0001). CYCLO-Trac was suggested to be useful in obtaining a reliable data on a daily basis within our hospital.
Keywords
シクロスポリン
モノクロナル抗体
ラジオイムノアッセイ法
腎移植
肝移植
Published Date
1993-02-27
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
227
End Page
229
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_227/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma