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ID 30749
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Author
Komiyama, Takamitsu
Nishida, Keiichiro Kaken ID publons researchmap
Yorimitsu, Masanori
Doi, Hideyuki
Miyazawa, Shinichi
Kitamura, Ai
Yoshida, Aki
Nasu, Yoshihisa
Abstract
Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
Keywords
spontaneous hypertensive rats
insulin like growth factor-1
vascular endothelial growth factor
ossification disturbance
osteonecrosis
Amo Type
Article
Published Date
2006-06
Publication Title
Acta Medica Okayama
Volume
volume60
Issue
issue3
Publisher
Okayama University Medical School
Start Page
141
End Page
148
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT