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Author Sogawa, Chiharu| Eguchi, Takanori| Tran, Manh Tien| Ishige, Masayuki| Trin, Kilian| Okusha, Yuka| Taha, Eman Ahmed| Lu, Yanyin| Kawai, Hotaka| Sogawa, Norio| Takigawa, Masaharu| Calderwood, Stuart K.| Okamoto, Kuniaki| Kozaki, Ken-Ichi|
Keywords drug repositioning/repurposing three-dimensional (3D) culture tumoroids dopamine transporter (DAT) benztropine signal transducer and activator of transcription (STAT) circulating tumor cell (CTC)
Published Date 2020-02-24
Publication Title Cancers
Volume volume12
Issue issue2
Publisher MDPI
Start Page 523
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32102440
DOI 10.3390/cancers12020523
Web of Science KeyUT 000522477300269
Related Url isVersionOf https://doi.org/10.3390/cancers12020523
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Author Shoji, Masaki| Ueda, Masako| Nishioka, Megumi| Minato, Hiroki| Seki, Masahide| Harada, Kenichi| Kubo, Miwa| Fukuyama, Yoshiyasu| Suzuki, Yutaka| Aoyama, Eriko| Takigawa, Masaharu| Kuzuhara, Takashi|
Keywords CCN signaling pathway CCN2 Jiadifenolide Neurotrophin iPS
Published Date 2019-11-05
Publication Title Biochemical and Biophysical Research Communications
Volume volume519
Issue issue2
Publisher Elsevier
Start Page 309
End Page 315
ISSN 0006291X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 31506177
DOI 10.1016/j.bbrc.2019.09.003
Web of Science KeyUT 00506404800015
Related Url isVersionOf https://doi.org/10.1016/j.bbrc.2019.09.003
Author Tomita, Nao| Hattori, Takako| Itoh, Shinsuke| Aoyama, Eriko| Yao, Mayumi| Yamashiro, Takashi| Takigawa, Masaharu|
Published Date 2013-03-28
Publication Title PLoS ONE
Volume volume8
Issue issue3
Content Type Journal Article
Author Itoh, Shinsuke| Hattori, Takako| Tomita, Nao| Aoyama, Eriko| Yutani, Yasutaka| Yamashiro, Takashi| Takigawa, Masaharu|
Published Date 2013-08-12
Publication Title PLoS ONE
Volume volume8
Issue issue8
Content Type Journal Article
Author Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2008-06
Publication Title Tissue Engineering Part A
Volume volume14
Issue issue6
Content Type Journal Article
Author Hoshijima, Mitsuhiro| Hattori, Takako| Aoyama, Eriko| Nishida, Takashi| Yamashiro, Takashi| Takigawa, Masaharu|
Published Date 2012-10
Publication Title FEBS Journal
Volume volume279
Issue issue19
Content Type Journal Article
Author Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
Published Date 2011-06-03
Publication Title Biochemical and Biophysical Research Communications
Volume volume409
Issue issue2
Content Type Journal Article
Author Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi|
Published Date 2008-02-01
Publication Title Biochemical and Biophysical Research Communications
Volume volume366
Issue issue1
Content Type Journal Article
Author Moritani, Norifumi H| Kubota, Satoshi| Sugahara, Toshio| Takigawa, Masaharu|
Published Date 2005-04-15
Publication Title Cell Communication and Signaling
Volume volume3
Issue issue1
Content Type Journal Article
Author Chujo, Sonoko| Shirasaki, Fumiaki| Kawara, Shigeru| Inagaki, Yutaka| Kinbara, Takuro| Inaoki, Makoto| Takigawa, Masaharu| Takehara, Kazuhiko|
Published Date 2004-12
Publication Title Journal of Cellular Physiology
Volume volume203
Issue issue2
Content Type Journal Article
Author Asano, Masahiro| Kubota, Satoshi| Nakanishi, Tohru| Nishida, Takashi| Yamaai, Tomoichiro| Yosimichi, Gen| Ohyama, Kazumi| Sugimoto, Tomosada| Murayama, Yoji| Takigawa, Masaharu|
Published Date 2005-10-05
Publication Title Cell Communication and Signaling
Volume volume3
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/30956
FullText URL fulltext.pdf
Author Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi|
Abstract <p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p>
Keywords IL-4 MMP cathepsin B mechanical stress aggrecanase
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 126
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464888
Web of Science KeyUT 000255297600008
JaLCDOI 10.18926/AMO/30739
FullText URL fulltext.pdf
Author Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu|
Abstract The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis.
Keywords neurotrophin Trk distraction osteogenesis mechanical stress
Amo Type Article
Published Date 2006-10
Publication Title Acta Medica Okayama
Volume volume60
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17072373
Web of Science KeyUT 000241509000003