FullText URL Mod_Rheumatol_26_5_730.pdf
Author Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi|
Keywords Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis
Note This is an Accepted Manuscript of an article published by Taylor & Francis Group
Published Date 2016-03-11
Publication Title Modern Rheumatology
Volume volume26
Issue issue5
Publisher Taylor & Francis
Start Page 730
End Page 737
ISSN 1439-7595
NCID AA1157187X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26873424
DOI 10.3109/14397595.2016.1140274
Web of Sience KeyUT 000393120600018
Related Url https://doi.org/10.3109/14397595.2016.1140274
Title Alternative The perception of chronic kidney disease in a general population in Okayama, Japan : 2015
Author Uchida, Haruhito A.| Sugiyama, Hitoshi| Miyazaki, Masashi| Wada, Jun| Shikata, Kenichi| Kashihara, Naoki| Makino, Hirofumi|
Abstract  Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. The present study investigated the perception of CKD in a general population in Okayama. In October and November 2015, a questionnaire survey was distributed by 12 medical centers in five medical districts in Okayama prefecture. A total of 7,022 respondents who underwent their physical checkup at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent's familiarity with the term "CKD," only 4% of the respondents answered "know it well" and 10% answered "unfamiliar." In contrast, in response to a questionnaire item asking about the respondent's familiarity with "chronic kidney disease," 27% answered "know it well" and 38% answered "unfamiliar." The leading avenue by which the respondents learned about CKD/chronic kidney disease was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component which the respondents considered essential for the diagnosis of CKD/chronic kidney disease was proteinuria. A stratified analysis demonstrated a higher recognition of “CKD" or “chronic kidney disease" in the medical districts in northern Okayama prefecture compared to southern Okayama prefecture. These results indicated that the awareness of CKD in Okayama prefecture is still inadequate. Many people did not appear to realize that the term “CKD" represents "chronic kidney disease". Further continuous public education efforts are required to enlighten people about CKD/chronic kidney disease.
Keywords 慢性腎臓病 (chronic kidney disease) CKD 認知度 (perception) 岡山県 (Okayama) 医療圏別 (medical distinct)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 101
End Page 105
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.101
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.101
Title Alternative Clinical Research Core Center and Okayama University
Author Makino, Hirofumi|
Keywords オール岡山大学 臨床研究中核病院 橋渡し研究加速ネットワークプログラム事業
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 45
End Page 49
ISSN 0030-1558
Official Url http://www.okayama-u.ac.jp/user/oma/|
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.45
Author Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi|
Published Date 2014-05-25
Publication Title PLOS ONE
Volume volume9
Issue issue3
Content Type Journal Article
Author Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
Published Date 2014-01-22
Publication Title PLOS ONE
Volume volume9
Issue issue1
Content Type Journal Article
Author Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun|
Published Date 2015
Publication Title Scientific reports
Volume volume5
Content Type Journal Article
Author Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi|
Published Date 2015-03
Publication Title Stem cells
Volume volume33
Issue issue3
Content Type Journal Article
Title Alternative Advances in Diabetology, The 49th Annual Post Graduate Course
FullText URL 127_167.pdf
Author Makino, Hirofumi|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 167
End Page 168
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.167
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.167
NAID 130005096244
JaLCDOI 10.18926/AMO/53117
FullText URL 69_1_1.pdf
Author Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi|
Abstract Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells.
Keywords prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus
Amo Type Original Article
Published Date 2015-02
Publication Title Acta Medica Okayama
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703166
Web of Sience KeyUT 000349740300001
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53128
Author Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi|
Published Date 2014-04-25
Publication Title Biochemical and Biophysical Research Communications
Volume volume447
Issue issue1
Content Type Journal Article
Author Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi|
Published Date 2013-10-22
Publication Title International Journal of Nephrology and Renovascular Disease
Volume volume6
Content Type Journal Article
Author Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi|
Published Date 2013-10-15
Publication Title PLoS ONE
Volume volume8
Issue issue10
Content Type Journal Article
Author Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi|
Published Date 2013-12-18
Publication Title International Journal of Nephrology and Renovascular Disease
Volume volume7
Content Type Journal Article
Author Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi|
Published Date 2013-12-05
Publication Title Molecular and Cellular Endocrinology
Volume volume381
Issue issue1-2
Content Type Journal Article
JaLCDOI 10.18926/AMO/52789
FullText URL 68_4_235.pdf
Author Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi|
Abstract The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
Keywords microalbuminuria type 2 diabetes mellitus remission regression
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 235
End Page 241
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145409
Web of Sience KeyUT 000340687500005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52828
JaLCDOI 10.18926/AMO/52788
FullText URL 68_4_219.pdf
Author Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi|
Abstract Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
Keywords chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145408
Web of Sience KeyUT 000340687500004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52824
Author Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi|
Published Date 2013-02
Publication Title Clinical and Experimental Nephrology
Volume volume17
Issue issue1
Content Type Journal Article
Author Kagawa, Hidetoshi| Hiromasa, Tsutomu| Hara, Takayuki| Takaki, Ayako| Yamanaka, Ryutaro| Sada, Ken-ei| Makino, Hirofumi|
Published Date 2012-10
Publication Title Clinical and Experimental Nephrology
Volume volume16
Issue issue5
Content Type Journal Article
Author Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
Published Date 2013-02-19
Publication Title PLoS ONE
Volume volume8
Issue issue2
Content Type Journal Article
Title Alternative Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
FullText URL 126_1.pdf
Author Miyamoto, Satoshi| Shikata, Kenichi| Miyasaka, Kyoko| Okada, Shinichi| Sasaki, Motofumi| Kodera, Ryo| Hirota, Daisho| Kajitani, Nobuo| Takatsuka, Tetsuharu| Kataoka Usui, Hitomi| Nishishita, Shingo| Horiguchi Sato, Chikage| Funakoshi, Akihiro| Nishimori, Hisakazu| Uchida, Haruhito Adam| Ogawa, Daisuke| Makino, Hirofumi|
Keywords cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 1
End Page 6
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.1